Author Andre Dubus III received more than 100 offers from film studios who wanted to make his book into a feature.
In the scene near the end of the movie where Kathy pulls into her driveway and tries to shoot herself, Jennifer Connelly accidentally put the car in "reverse" instead of "park", and almost severely damaged the camera positioned in the car door. After Connelly apologized profusely, she was urged by the director to continue the scene, and it ended up being one of the best takes. This is the take shown in the final print.
Ben Kingsley was given a copy of the novel "House of Sand and Fog" by author Andre Dubus III's wife, before he was ever approached to star in the movie.
The "House" of the title is located at "34 Bisgrove Street" in the fictional "Pacific County", California.
Numerous location shots in Northern California establish the action as occurring in the San Francisco Bay Area. The actual house was over 400 miles away, in Malibu.
In the scenes on the rooftop porch, telephone poles and wires are prominently visible. These were added by the production crew, to make the neighborhood where filming occurred seem more middle-class.