Whoopi Goldberg's daughter, Alex Martin, appears in this movie as one of the classroom children. She says the "Yo Mama" line about Skittles.
Deedee Magno, one of the music students Sister Mary Clarence (Whoopi Goldberg) teaches, was once a member of the early 90s pop group The Party - a group manufactured by Disney (also the producer of Sister Act 2).
Whoopi Goldberg was very unhappy making the first film and made this sequel only after Disney decided to finance her dream project, Sarafina! (1992)
Great care was taken to either partially or completely hide James Coburn's hands, which are obviously suffering the effects of arthritis.
When the students are on the basketball court, Lauryn Hill's character, Rita, starts rapping. Her rap wasn't a part of the script.