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unknown
Year:
1993
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1994
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unknown
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest | |
| Billy Joel | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tom Brokaw | ... | Himself - Cameo | |
| Paul Newman | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Robin Williams | ... | Himself - Guest | |
| John Mellencamp | ... | Himself - Musical Guest | |
| Jonathan Estrada | ... | Himself (as Jon Estrada) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Demi Moore | ... | Herself - Guest | |
| Bev Tanner | ... | Herself - Guest | |
| The Spin Doctors | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Martin Short | ... | Himself - Guest | |
| Cyndi Lauper | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Andy Dick | ... | Donnie (uncredited) |
| David Letterman | ... | Himself - Host | |
| Debra Winger | ... | Herself - Guest | |
| Soul Asylum | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Casey Kasem | ... | Himself - Cameo | |
| Regis Philbin | ... | Himself - Cameo |
| David Letterman | ... | Himself - Host | |
| Richard Lewis | ... | Himself - Guest | |
| Shawn Burroughs | ... | Himself - Guest | |
| Midnight Oil | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Michael J. Fox | ... | Himself | |
| Rosie Perez | ... | Herself | |
| Johnny Petraglia | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Kim Basinger | ... | Herself | |
| Al Gore | ... | Himself | |
| Chris Isaak | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Ellen Barkin | ... | Herself | |
| Lenny Kravitz | ... | Himself | |
| Chris 'Mad Dog' Russo | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Bob Denver | ... | Himself | |
| Roger Ebert | ... | Himself | |
| Robert Plant | ... | Himself | |
| David Sanborn | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Gene Siskel | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Nicole Kidman | ... | Herself - Guest | |
| Laura Dern | ... | Herself - Guest | |
| Gloria Estefan | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Elle Macpherson | ... | Herself - Guest | |
| Vince Vaughn | ... | Himself - Guest | |
| Jewel Kilcher | ... | Herself - Musical Guest (as Jewel) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Borden | ... | Himself - Relating to his Prom Nightmares | |
| Christian Breheney | ... | Himself - Relating to his Prom Nightmares | |
| Rupert Jee | ... | Himself - Dramatizing Late Show staffers memories of Prom Nightmares | |
| Eric Kaplan | ... | Himself - Relating to his Prom Nightmares | |
| Rodney Munoz | ... | Himself - Relating to his Prom Nightmares | |
| Matt Roberts | ... | Himself - Relating to his Prom Nightmares | |
| Richard Simmons | ... | Himself - Dramatizing Late Show staffers memories of Prom Nightmares | |
| Eric Stangel | ... | Himself - Relating to his Prom Nightmares |
| David Letterman | ... | Himself - Host | |
| Matt Lauer | ... | Himself - Guest | |
| Holiefield Ruthie | ... | Herself - Guest (as Ruthie Bolton-Holifield) | |
| The Mighty Mighty Bosstones | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Pierce Cravens | ... | Young Boy (uncredited) | |
| Maria Di Angelis | ... | Young Girl (uncredited) |
| David Letterman | ... | Himself - Host | |
| Gene Siskel | ... | Himself - Guest (as Siskel) | |
| Roger Ebert | ... | Himself - Guest (as Ebert) | |
| Dermot Mulroney | ... | Himself - Guest | |
| King Charles Troup | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Eric Kaplan | ... | Himself - 'Riverdancing' | |
| Michael Z. McIntee | ... | Himself - 'Riverdancing' (as Mike McIntee) | |
| Gerard Mulligan | ... | Himself - 'Riverdancing' (as Gerry Mulligan) | |
| Jim Peterson | ... | Himself - 'Riverdancing' |
| David Letterman | ... | Himself - Host | |
| Nicholas Turturro | ... | Himself - Guest (as Nick Turturro) | |
| Daisy Fuentes | ... | Herself - Guest | |
| Mötley Crüe | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Kevin Costner | ... | Himself | |
| Tyra Banks | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Brad Daluiso | ... | Himself | |
| Jim Fassel | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Danny Kanell | ... | Himself | |
| Tony Mendez | ... | Himself | |
| Bobby Waldron | ... | Cpt. Ed Smith |
| David Letterman | ... | Himself - Host | |
| Cher | ... | Herself - Guest / Also Musical Guest | |
| Jerry Springer | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| John Bundy | ... | Himself - Magician | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Tony Mendez | ... | Himself - Drinks a blue card | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| Bobby Waldron | ... | Army Srgt. |
| David Letterman | ... | Himself - Host | |
| Natalie Portman | ... | Herself - Guest | |
| Travis Pastrana | ... | Himself - Guest | |
| Ted Alexandro | ... | Himself - Guest / Stand-up Comedian | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Nadine Hennelly | ... | Herself - Late Show Model (uncredited) | |
| Justin T. Milner | ... | Himself (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host (credit only) | |
| Janeane Garofalo | ... | Herself - Guest Host | |
| Bob Odenkirk | ... | Himself - Guest | |
| David Cross | ... | Himself - Guest | |
| Zach Galifianakis | ... | Himself - Guest | |
| Old 97's | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor (credit only) |
| David Letterman | ... | Himself - Host | |
| Ringo Starr | ... | Himself - Guest / Musical Guest | |
| Jane Krakowski | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Don Rickles | ... | Himself - Guest | |
| Ween | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Madonna | ... | Herself - Guest / Also Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| John McEnroe | ... | Himself - Guest | |
| Youssou N'Dour | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Thora Birch | ... | Herself | |
| Alan Kalter | ... | Himself - Announcer | |
| Dorothy Mengering | ... | Herself |
| David Letterman | ... | Himself - Host | |
| Tom Arnold | ... | Himself - Guest | |
| David Sedaris | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Kenny Bräck | ... | Himself - Playing Guitar |
| David Letterman | ... | Himself - Host | |
| Lance Armstrong | ... | Himself - Guest | |
| Thora Birch | ... | Herself - Guest | |
| Jamie O'Neal | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Dan Rather | ... | Himself - Guest | |
| Regis Philbin | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tori Amos | ... | Herself - Musical Guest | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Chris Elliott | ... | Himself - Guest | |
| Eliza Dushku | ... | Herself - Guest | |
| Dixie Chicks | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Presenter (segment "May We See Your Photos - Please?") | |
| Alan Kalter | ... | Himself - Announcer | |
| Michael Zegen | ... | Dwight the Troubled Teen (uncredited) |
| David Letterman | ... | Himself - Host | |
| Allison Janney | ... | Herself - Guest | |
| Martin Scorsese | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Natasha Richardson | ... | Herself - Guest | |
| Mike Birbiglia | ... | Himself - Guest / Stand-up Comedian | |
| David Gray | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Dan Patrick | ... | Himself - Cameo | |
| Nadine Hennelly | ... | Herself - Late Show Model (uncredited) | |
| Anna Jack | ... | Herself - Hula-Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| John C. Reilly | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Sirajul Islam | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Mujibur Rahman | ... | Himself | |
| Toots Thielemans | ... | Himself - Musical Support / Sitting in with the band | |
| Nadine Hennelly | ... | Herself (uncredited) | |
| Andrea Sande | ... | Herself (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jane Krakowski | ... | Herself - Guest | |
| Jim Boeheim | ... | Himself - Guest | |
| Pete Yorn | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Ader | ... | CBS Sports Reporter (uncredited) |
| David Letterman | ... | Himself - Host | |
| Liam Lynch | ... | Himself - Musical Guest | |
| Tobey Maguire | ... | Himself | |
| Aron Ralston | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest | |
| Pete Sampras | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Host | |
| Alan Kalter | ... | Himself - Announcer | |
| Art Kelly | ... | Himself - Survivor of Electric Power Blackout (voice) | |
| Harold Larkin | ... | Harold - Mars Attack Victim | |
| Nadine Hennelly | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Spade | ... | Himself - Guest | |
| Bob Sarlatte | ... | Himself - Guest | |
| Maroon 5 | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Susan Hum | ... | Sum Hum - Costume Designer | |
| Alan Kalter | ... | Himself - Announcer | |
| Art Kelly | ... | Himself - Survivor of Electric Power Blackout (voice) | |
| Serena Williams | ... | Herself - Top Ten List Presenter | |
| Venus Williams | ... | Herself - Top Ten List Presenter |
| David Letterman | ... | Himself - Host | |
| Steve Martin | ... | Himself - Guest | |
| Shannon Eis | ... | Herself - Presents new toys for christmas | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Tony Mendez | ... | Himself - Cue Card Master |
| David Letterman | ... | Himself - Host | |
| Patricia Heaton | ... | Herself - Guest | |
| Kate Bosworth | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Richard Gephardt | ... | Himself - Top Ten List Presenter (as Dick Gephardt) | |
| Alan Kalter | ... | Himself - Announcer | |
| Leslie Moonves | ... | Himself - On the phone with Dave (voice) (as Les Moonves) |
| David Letterman | ... | Himself - Host | |
| Amy Sedaris | ... | Herself - Guest / 4am Tour Guide | |
| Robert Sullivan | ... | Himself - Guest / Rat Expert Author | |
| Modest Mouse | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Borden | ... | Bob - Overslept Staffer | |
| Jimmy Gallagher | ... | Himself - NYPD Officer | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Darian Shannon | ... | Himself - NYPD Officer | |
| Eric Stangel | ... | Eric - Awake Staffer | |
| Michael Z. McIntee | ... | Himself - Breakfast Eater (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Alan Grier | ... | Himself - Guest | |
| Britton Keeshan | ... | Himself - Guest | |
| The Von Bondies | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | George - Hangover Expert | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Gerard Mulligan | ... | President Bill Clinton (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Smith | ... | Himself - Guest | |
| Jet | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Natalie Coughlin | ... | Herself - Guest | |
| Carla Gugino | ... | Herself - Guest | |
| Gavin DeGraw | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Not falling for a scam | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Drew Barrymore | ... | Herself | |
| Aron Ralston | ... | Himself |
| Neve Campbell | ... | Herself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Andrew Vannata | ... | Audience Page |
| David Letterman | ... | Himself - Host | |
| Howard Dean | ... | Himself - Guest (as Governor Howard Dean) | |
| Franz Ferdinand | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dorothy Chambers | ... | Herself - Late Show Security Officer (archive footage) | |
| George Clarke | ... | Host of 'It's a Fact' | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jamie Foxx | ... | Himself - Guest | |
| Davy Rothbart | ... | Himself - Guest | |
| The Killers | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| Alan Kalter | ... | Himself - Announcer | |
| Stephanie Birkitt | ... | Herself | |
| Johnny Dark | ... | World's Oldest Page | |
| Pat Farmer | ... | Himself | |
| Biff Henderson | ... | Himself | |
| Rupert Jee | ... | Himself | |
| Harold Larkin | ... | Himself | |
| Tony Mendez | ... | Himself | |
| Maria Pope | ... | Herself | |
| Doug Prescott | ... | Himself (as Doug Roberts) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Kenny Sheehan | ... | Himself | |
| Scott Wayne-Prescott | ... | Himself (as Scott Prescott) | |
| Elijah Wood | ... | Himself | |
| Margaret Hall | ... | Lady Who Receives Flowers (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Hi-Ho Girl (uncredited) |
| David Letterman | ... | Himself - Host | |
| Adam Sandler | ... | Himself - Guest | |
| Shannon Eis | ... | Herself - Presents new toys for christmas | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Annette Guardabascio | ... | Herself - Gives her take on Bernard Kerik | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Al Franken | ... | Himself - Guest | |
| Matthew Fox | ... | Himself - Guest | |
| Nanci Griffith | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Deion Branch | ... | Himself - Top Ten List Presenter | |
| Troy Brown | ... | Himself - Top Ten List Presenter | |
| Tedy Bruschi | ... | Himself - Top Ten List Presenter | |
| Roosevelt Colvin | ... | Himself - Top Ten List Presenter | |
| Larry Izzo | ... | Himself - Top Ten List Presenter | |
| Ted Johnson | ... | Himself - Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer | |
| Matt Light | ... | Himself - Top Ten List Presenter | |
| Willie McGinest | ... | Himself - Top Ten List Presenter | |
| Adam Vinatieri | ... | Himself - Top Ten List Presenter | |
| Mike Vrabel | ... | Himself - Top Ten List Presenter | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Smith | ... | Himself - Guest | |
| Tom Brady | ... | Himself - Guest | |
| Biff Henderson | ... | Himself - Visits Superbowl XXXIX | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tully Banta-Cain | ... | Himself - Superbowl XXXIX Player | |
| Matt Chatham | ... | Himself - Superbowl XXXIX Player | |
| Bill Clinton | ... | Himself - Superbowl XXXIX Visitor (as Former President Bill Clinton) | |
| Roosevelt Colvin | ... | Himself - Superbowl XXXIX Player (as Colvin Rosevelt) | |
| Sean 'P. Diddy' Combs | ... | Himself - Superbowl XXXIX Visitor (as Puff Daddy) | |
| Norman Douglass | ... | Himself - Stuntman jumping of roof while on fire | |
| Daniel Graham | ... | Himself - Superbowl XXXIX Player | |
| M.C. Hammer | ... | Himself - Superbowl XXXIX Visitor (as Hammer) | |
| Randy Jackson | ... | Himself - Superbowl XXXIX Visitor | |
| Robert Kraft | ... | Himself - Superbowl XXXIX Visitor | |
| Ashton Kutcher | ... | Himself - Superbowl XXXIX Visitor | |
| Stephen Neal | ... | Himself - Superbowl XXXIX Player | |
| Lionel Richie | ... | Himself - Superbowl XXXIX Visitor | |
| Chris Rock | ... | Himself - Superbowl XXXIX Visitor | |
| Keith Traylor | ... | Himself - Superbowl XXXIX Player |
| David Letterman | ... | Himself - Host | |
| Kevin James | ... | Himself - Guest | |
| Aishwarya Rai | ... | Herself - Guest | |
| 3 Doors Down | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Hyde Pierce | ... | Himself - Guest | |
| Howie Day | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Chocolate Referee | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Deborah Lynn | ... | Herself - Intuitive | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Michael Z. McIntee | ... | Seth Garber - Contest Winner (uncredited) |
| David Letterman | ... | Himself - Host | |
| Billy Crystal | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Vernon Campbell | ... | Top Ten Bald Men (voice) (unconfirmed) (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Bill Burr | ... | Himself - Guest / Stand-up Comedian | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Unwritten Law | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Leslie Moonves | ... | Himself (as Les Moonves) | |
| Erica Dahm | ... | Herself - Woman escorting Dr. Phil (uncredited) | |
| Nicole Dahm | ... | Herself - Woman escorting Dr. Phil (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charlie Tschirhart | ... | Himself - Kid Scientist | |
| Robin Peterson | ... | Herself - Kid Scientist | |
| Michelle Ikoma | ... | Herself - Kid Scientist | |
| Keanu Reeves | ... | Himself - Guest | |
| Michael Bublé | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Borden | ... | Himself - Reports from Poconos | |
| Al Chez | ... | Horn Section Yay-Sayer #2 (uncredited) | |
| Bruce Kapler | ... | Horn Section Yay-Sayer #3 (uncredited) | |
| Tom Malone | ... | Horn Section Yay-Sayer #1 (uncredited) |
| David Letterman | ... | Himself - Host | |
| Roseanne | ... | Herself - Guest / Also Stand-up Comedian | |
| Rachel Weisz | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) | |
| Bradford N. Smith | ... | Himself (unconfirmed) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Barbara Walters | ... | Herself - Guest | |
| Rachel Bilson | ... | Herself - Guest | |
| Kings of Leon | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Harold Larkin | ... | Himself - Host of 'Sidewalk Idol' | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Michael J. Fox | ... | Himself - Guest | |
| Amanda Bynes | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Rupert - Bringer of final thoughts | |
| Alan Kalter | ... | Himself - Announcer / Various |
| David Letterman | ... | Himself - Host | |
| John Travolta | ... | Himself - Guest | |
| Tony Kornheiser | ... | Himself - Guest | |
| Michael Wilbon | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Stephanie Birkitt | ... | Herself - Hands out prizes to the audience (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ricky Gervais | ... | Himself - Guest | |
| Rachael Ray | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Model for Lego portrait (also archive footage) | |
| Susan Hum | ... | Sue - Unprepared predictor of Academy Awards (as Sue Hum) | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Nathan Sawaya | ... | Himself - Expert Lego Builder | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dwayne Johnson | ... | Himself - Guest (as The Rock) | |
| Solomon Burke | ... | Himself - Musical Guest | |
| Jay Quinlan | ... | Himself - Jumps with a Snowmobile on 53rd Street | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kristin Chenoweth | ... | Herself - Guest | |
| Johnny Lechner | ... | Himself - Guest | |
| Ludacris | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Teddy Sears | ... | Blind Justice (uncredited) |
| David Letterman | ... | Himself - Host | |
| Michael Chiklis | ... | Himself - Guest | |
| Gary Mule Deer | ... | Himself - Guest / Performs Stand-up Comedy | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Shannon Eis | ... | Herself - Presenting new summer toys | |
| Biff Henderson | ... | Himself - Drives a go-cart | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| Nick Cirillo | ... | Himself | |
| Paul Reiser | ... | Himself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Spoon |
| Stephen Colbert | ... | Himself | |
| Heloise | ... | Herself | |
| The Black Eyed Peas | ... | Themselves | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| David Letterman | ... | Himself - Host | |
| Tatum O'Neal | ... | Herself - Guest | |
| Jeff MacGregor | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Performs a Pizza Taste-off | |
| Alan Kalter | ... | Himself - Announcer | |
| Rute | ... | Herself - Late Show Model / Out on a pizza-hunt | |
| Andrea Sande | ... | Herself - Late Show Model / Out on a pizza-hunt | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) |
| David Letterman | ... | Himself - Host | |
| Philip Seymour Hoffman | ... | Himself - Guest | |
| Paul Teutul Jr. | ... | Himself - Guest | |
| Paul Teutul Sr. | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Stephanie Birkitt | ... | Herself | |
| Pat Farmer | ... | Himself - Stage Hand | |
| Biff Henderson | ... | Himself - Stage Manager / Modelling for a cheese sculpture | |
| Troy Landwehr | ... | Himself - Sculpturing Biff Henderson in cheese | |
| Michael Teutul | ... | Himself |
| David Letterman | ... | Himself - Host | |
| Tim Russert | ... | Himself - Guest | |
| Henri Arnold | ... | Himself - Guest | |
| Cat Power | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Stage Hand / Causing the light in the theatre to flicker with his blowdryer | |
| Teenie Hodges | ... | Himself - Sitting in with the band for musical support on guitar | |
| Rupert Jee | ... | Himself - Kicking footballs from the roof of the Ed Sullivan Theatre |
| David Letterman | ... | Himself - Host | |
| Dwyane Wade | ... | Himself - Guest | |
| Amy Sedaris | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bruce Kapler | ... | Himself - Signs for a package | |
| Morningwood | ... | Musical Guest | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Colin Farrell | ... | Himself - Guest | |
| India.Arie | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Shannon Eis | ... | Herself - Presents new summer toys | |
| Susan Hum | ... | Susan Hum | |
| Rupert Jee | ... | Himself - Host's 'What's on the Ipod?' | |
| Darrin Bennett | ... | Floyd Landis - Riding trough the Ed Sullivan Theater on a bicycle (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Maria Sharapova | ... | Herself - Guest | |
| Martha Stewart | ... | Herself - Guest | |
| Justin Timberlake | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tony Mendez | ... | Himself - Cue Card Boy | |
| Johnny Dark | ... | Rude Dude (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ashton Kutcher | ... | Himself - Guest | |
| Sam Hornish Jr. | ... | Himself - Guest | |
| T.V. On The Radio | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Stage Hand | |
| Alan Kalter | ... | Himself - Announcer | |
| Susan Aileen Cremin | ... | Cheerleader (uncredited) | |
| Johnny Dark | ... | Doctor (uncredited) | |
| Mark Delabarre | ... | Various Characters (uncredited) | |
| Stephen Seidel | ... | Basketball Player (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dwayne Johnson | ... | Himself - Guest (as Dwayne 'The Rock' Johnson) | |
| Norm MacDonald | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Jeff Burton | ... | Himself - Top Ten List Presenter | |
| Kyle Busch | ... | Himself - Top Ten List Presenter | |
| Dave Dorsett | ... | Himself - Camera Operator | |
| Dale Earnhardt Jr. | ... | Himself - Top Ten List Presenter | |
| Jeff Gordon | ... | Himself - Top Ten List Presenter | |
| Denny Hamlin | ... | Himself - Top Ten List Presenter | |
| Kevin Harvick | ... | Himself - Top Ten List Presenter | |
| Rupert Jee | ... | Himself - Host's 'What's on the Ipod?' | |
| Jimmie Johnson | ... | Himself - Top Ten List Presenter | |
| Kasey Kahne | ... | Himself - Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer | |
| Matt Kenseth | ... | Himself - Top Ten List Presenter | |
| Mark Martin | ... | Himself - Top Ten List Presenter | |
| Johnny Dark | ... | Mets Fan (uncredited) | |
| Mary Ann Hannon | ... | Dave's Diner Waitress (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Anne Heche | ... | Herself - Guest | |
| Luke R. Ravenstahl | ... | Himself - Guest (as Luke Ravenstahl) | |
| The Who | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Susan Hum | ... | Sue Hum - Brings in a cat | |
| Art Kelly | ... | Art - Switchboard Operator | |
| Jude Brennan | ... | Jude - Producer in Cold Open Sketch (uncredited) | |
| Ricardo Cordero | ... | Bob Zick / Character (uncredited) | |
| Johnny Dark | ... | Frustrated Remote Control Owner (uncredited) | |
| Mary Ann Hannon | ... | Dave's Diner Waitress (uncredited) |
| David Letterman | ... | Himself - Host | |
| Johnny Knoxville | ... | Himself - Guest | |
| Rachael Ray | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Tommy O'Brien | ... | Himself - Stage Hand | |
| Johnny Dark | ... | Tailor (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Frank Caliendo | ... | Himself - Guest | |
| Rachael Harris | ... | Herself - Guest | |
| Xzibit | ... | Himself - Musical Guest | |
| Phil Pfister | ... | Himself - Flips a car on 53rd Street | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Rachel Weisz | ... | Herself - Guest | |
| David Rakoff | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Morningwood | ... | Themselves |
| David Letterman | ... | Himself - Host | |
| Kate Winslet | ... | Herself - Guest | |
| Tom Waits | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Susan Aileen Cremin | ... | Cheerleader (uncredited) | |
| Mark Delabarre | ... | Various Characters (uncredited) | |
| Stephen Seidel | ... | Basketball Player (uncredited) |
| David Letterman | ... | Himself - Host | |
| Matt Lauer | ... | Himself - Guest | |
| Artie Lange | ... | Himself - Guest | |
| Augustana | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Julianne Moore | ... | Herself - Guest | |
| Madonna | ... | Herself - Guest | |
| The Hold Steady | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tom Catusi | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Ricky Gervais | ... | Himself - Guest | |
| Forest Whitaker | ... | Himself - Guest | |
| The Shins | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself - Building Engineer / Presenting 'It's a fact with George Clarke' | |
| Rupert Jee | ... | Himself - Trying out pantsuits | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host (credit only) | |
| Adam Sandler | ... | Himself - Guest Host | |
| Don Cheadle | ... | Himself - Guest | |
| Danica Patrick | ... | Herself - Guest | |
| Todd Barry | ... | Himself - Guest / Stand-up Comedian | |
| Lucinda Williams | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor |
| Dinosaur Jr. | ... | Themselves | |
| Kirsten Dunst | ... | Herself | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Michael Maniaci | ... | Himself- Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tobey Maguire | ... | Himself - Guest | |
| John Byner | ... | Himself - Guest / Impressionist | |
| Modest Mouse | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Ricardo Cordero | ... | Bob Zicks | |
| Topher Grace | ... | Tobey Maguire / Topher Grace | |
| Biff Henderson | ... | Himself - Host's 'What's on the Ipod?' | |
| Alan Kalter | ... | Himself - Announcer / Various | |
| Tom Catusi | ... | Sleeping Video Tape Editor (uncredited) |
| David Letterman | ... | Himself - Host | |
| Don Rickles | ... | Himself - Guest | |
| Michael Imperioli | ... | Himself - Guest | |
| Wilco | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Kenny Bräck | ... | Himself - Playing Guitar | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Masi Oka | ... | Himself - Top Ten List Presenter | |
| Chris Elliott | ... | Mac Computer (uncredited) | |
| Gerard Mulligan | ... | PC Computer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Luke Wilson | ... | Himself - Guest | |
| Rufus Wainwright | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Susan Hum | ... | Herself - Get's refused to participate in 'Know your current events' (as Sue) | |
| Stephanie Birkitt | ... | Herself - Hands out prizes to the audience (uncredited) | |
| Chris Elliott | ... | Mac Computer (uncredited) | |
| Gerard Mulligan | ... | PC Computer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kevin James | ... | Himself - Guest | |
| José Andrés | ... | Himself - Guest | |
| White Rabbits | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Kyle Duncan | ... | Himself - New York Pastry Chef | |
| Alan Kalter | ... | Himself - Announcer | |
| Tony Mendez | ... | Himself - Presenting 'How It's Made' | |
| Mark Odgers | ... | Himself - Jumping over a taxi-cab on 53rd Street | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kevin Bacon | ... | Himself - Guest | |
| Dalton Carriker | ... | Himself - Guest | |
| T.I. | ... | Himself - Musical Guest | |
| Wyclef Jean | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Hosting 'Psychic Soup' | |
| Deborah Lynn | ... | Herself - Playing 'Psychic Soup' | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Clinton | ... | Himself - Guest (as President Bill Clinton) | |
| Patti Scialfa | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Danny DeVito | ... | Himself - Guest | |
| Larry David | ... | Himself - Guest | |
| Avril Lavigne | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself | |
| Susan Hum | ... | Herself | |
| Johnny Dark | ... | Mark Twain (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jessica Alba | ... | Herself - Guest | |
| George Saunders | ... | Himself - Guest | |
| The Manchester Orchestra | ... | Themselves - Musical Guest (as 'Manchester Orchestra') | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Ronald Reagan dressed as Abraham Lincoln (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rachael Ray | ... | Herself - Guest | |
| Frank Rich | ... | Himself - Guest | |
| Arctic Monkeys | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Aaron Bing | ... | Himself - Trying to break the world record in 'Circular Breathing' with a saxophone | |
| Stuart Claxton | ... | Himself - Guinnes World Records Judge | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jodie Foster | ... | Herself - Guest | |
| Glen Hansard | ... | Himself - Musical Guest | |
| Markéta Irglová | ... | Herself - Musical Guest (as Marketa Irglova) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself - Building Engineer / Giving back-to-school advice | |
| Dave Dorsett | ... | Himself - Camera Operator / Giving back-to-school advice | |
| Biff Henderson | ... | Himself - Giving back-to-school advice | |
| Susan Hum | ... | Herself - Costume Designer / Giving back-to-school advice | |
| Rupert Jee | ... | Himself - Giving back-to-school advice | |
| Alan Kalter | ... | Himself - Announcer | |
| Gary Mintz | ... | Himself - Technical Maintenance Supervisor / Giving back-to-school advice | |
| Johnny Dark | ... | Mark Twain (uncredited) | |
| Karen Weatherwax | ... | French Tutor for Dave Dorsett (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Andy Kindler | ... | Himself - Guest | |
| Suzanne Vega | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Deborah Lynn | ... | Herself - Playing 'Psychic Sandwich' | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Viggo Mortensen | ... | Himself - Guest | |
| Katherine von Drachenberg | ... | Herself - Guest (as Kat Von D) | |
| Daughtry | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Clint Bowyer | ... | Himself - Top Twelve List Presenter | |
| Jeff Burton | ... | Himself - Top Twelve List Presenter | |
| Kurt Busch | ... | Himself - Top Twelve List Presenter | |
| Kyle Busch | ... | Himself - Top Twelve List Presenter | |
| Carl Edwards | ... | Himself - Top Twelve List Presenter | |
| Jeff Gordon | ... | Himself - Top Twelve List Presenter | |
| Denny Hamlin | ... | Himself - Top Twelve List Presenter | |
| Kevin Harvick | ... | Himself - Top Twelve List Presenter | |
| Jimmie Johnson | ... | Himself - Top Twelve List Presenter | |
| Matt Kenseth | ... | Himself - Top Twelve List Presenter | |
| Tony Stewart | ... | Himself - Top Twelve List Presenter | |
| Martin Truex Jr. | ... | Himself - Top Twelve List Presenter | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Martha Stewart | ... | Herself - Guest | |
| Fred Willard | ... | Himself - Guest | |
| Maya Arulpragasam | ... | Herself - Musical Guest (as M.I.A.) | |
| Billy Bob Thornton | ... | Himself - Top Ten List Presenter | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Johnny Dark | ... | Mark Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| Chamillionaire | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Chris Elliott | ... | Mac Computer (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) | |
| Gerard Mulligan | ... | PC Computer (uncredited) | |
| Slick Rick | ... | Himself - Musical Guest (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jamie Foxx | ... | Himself - Guest | |
| Jimmy Smits | ... | Himself - Guest | |
| Will i Am | ... | Himself - Musical Guest (as Will.I.Am) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Mary Apple | ... | Herself - Audience Member / Providing Dave with a heart shaped potato | |
| Jon Coombs | ... | Himself - Putting rubberbands over his head | |
| Darrin Bennett | ... | Floyd Landis - Riding trough the Ed Sullivan Theater on a bicycle (uncredited) | |
| George Clarke | ... | Himself - Building Engineer (uncredited) | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Walsh | ... | Herself - Guest | |
| Kevin Smith | ... | Himself - Guest | |
| Rascal Flatts | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Bill Scheft | ... | Himself - Writer |
| David Letterman | ... | Himself - Host | |
| Jennifer Garner | ... | Herself - Guest | |
| Ken Burns | ... | Himself - Guest | |
| Chaka Khan | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Chris Elliott | ... | Himself - Promoting 'Bionic Guy' | |
| Gerard Mulligan | ... | Himself - Promoting 'Bionic Guy' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Stewart J. Zully | ... | Hoodlum (uncredited) |
| David Letterman | ... | Himself - Host | |
| Whoopi Goldberg | ... | Herself - Guest | |
| Melissa Etheridge | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Jason Winn 'J.B. Destiny' Bareford | ... | Himself - Performing 'Stupid Human Tricks' | |
| Chris Hansen | ... | Himself - Performing 'Stupid Human Tricks' | |
| Mark Hayward | ... | Himself - Performing 'Stupid Human Tricks' | |
| Rupert Jee | ... | Himself - Dressed as 'Ugly Betty' |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Emile Hirsch | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Henry Rife | ... | Himself - Jumping over six taxicabs on an ATV |
| David Letterman | ... | Himself - Host | |
| Sean Penn | ... | Himself - Guest | |
| Barry Sonnenfeld | ... | Himself - Guest | |
| Ben Harper | ... | Himself - Musical Guest | |
| The Innocent Criminals | ... | Themselves - Musical Guests | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Brian Teta | ... | Himself - Segment Producer / Sharing his 'Memories of Regis' | |
| Dave Dorsett | ... | Himself - Late Show Camera Operator (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jude Law | ... | Himself - Guest | |
| Sarah Silverman | ... | Herself - Guest | |
| John Fogerty | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Sarah Billington | ... | Herself - Talent Coordinator / Sharing her 'Memories of Regis' | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Mark 'Johnny' Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Alec Baldwin | ... | Himself - Guest | |
| Faith Hill | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Anagnostakos | ... | Himself - Writers Intern / Attempting parallel parking on 53rd Street | |
| Stephanie Hearn | ... | Herself - Talent Intern / Attempting parallel parking on 53rd Street |
| David Letterman | ... | Himself - Host | |
| Nicollette Sheridan | ... | Herself - Guest | |
| Tony Snow | ... | Himself - Guest | |
| Rihanna | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Chris Elliott | ... | Himself - Plugging 'Skink, The Bounty Hunter' | |
| Gerard Mulligan | ... | Himself - Plugging 'Skink, The Bounty Hunter' |
| David Letterman | ... | Himself - Host | |
| Bob Newhart | ... | Himself - Guest | |
| Angela Kinsey | ... | Herself - Guest | |
| Iron & Wine | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Gary Mintz | ... | Himself - Technical Maintenance Supervisor / Sharing his 'Memories of Regis' | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| George Clooney | ... | Himself - Guest | |
| Kid Rock | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Celebrating Columbus Day by throwing things of The Ed Sullivan Theater roof | |
| Kenny Sheehan | ... | Himself - Tugging on a cigarette while assisting Pat throwing things of The Ed Sullivan Theater roof | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Jennifer Lopez | ... | Herself - Guest / Musical Guest | |
| Alan Greenspan | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager / Presenting 'What's in the Green Room?' | |
| Al Norwood | ... | Himself - Boom Operator | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Stephen Colbert | ... | Himself - Guest | |
| Eva Mendes | ... | Herself - Guest | |
| Queens of the Stone Age | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager / Giving bare-chested Alex Rodríguez a rubdown (archive footage) | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Pat Farmer | ... | Himself - Stage Hand / Bringing in a big box of meat from Gallagher's (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alex Rodríguez | ... | Himself - Getting a bare-chested rubdown from Biff Henderson (archive footage) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Anne Heche | ... | Herself - Guest | |
| Sue Johanson | ... | Herself - Guest | |
| Mariza | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Johnny Dark | ... | Vince - Crescent Springs Village Sales Representative (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Bill Scheft | ... | Himself - Writer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Halle Berry | ... | Herself - Guest | |
| Bill Hader | ... | Himself - Guest | |
| Eric Buss | ... | Himself - Performing Comedy Magic Act (as Spring Snake Symphony) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Dave Dorsett | ... | Himself - Late Show Camera Operator (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) | |
| Karen Weatherwax | ... | Santa Maria (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jake Gyllenhaal | ... | Himself - Guest | |
| Connie Britton | ... | Herself - Guest | |
| 50 Cent | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself - Building Engineer | |
| Megan Dougherty | ... | Herself - Intern | |
| Dan Fetter | ... | Fleeing guy chased by security guard | |
| Tyler Flowers | ... | Himself - Intern | |
| Jessica Holohan | ... | Herself - Intern | |
| Carrie Kemper | ... | Herself - Intern | |
| Phil Kessel | ... | Himself - Intern | |
| Anne McCarthy | ... | Herself - Intern | |
| Michael Z. McIntee | ... | Security Guard | |
| Mark Odgers | ... | Himself - Jumping over 5 interns on 53rd Street | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Tony Yayo | ... | Himself - Musical Guest (uncredited) |
| David Letterman | ... | Himself - Host | |
| Richard Simmons | ... | Himself - Guest | |
| Casey Affleck | ... | Himself - Guest | |
| Sondre Lerche | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| José Feliciano | ... | Himself - Surprise Musical Guest / Performing 'Old Turkey Buzzard' | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Dave Dorsett | ... | Himself - Late Show Camera Operator (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rebecca Romijn | ... | Herself - Guest | |
| Jimmie Walker | ... | Himself - Guest | |
| LeAnn Rimes | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Bill Scheft | ... | Himself - Writer | |
| Johnny Dark | ... | Johnny D (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Susan Hum | ... | Herself (uncredited) |
| David Letterman | ... | Himself - Host | |
| Steve Carell | ... | Himself - Guest | |
| Chris 'Mad Dog' Russo | ... | Himself - Guest (as Christopher 'Mad Dog' Russo) | |
| Band of Horses | ... | Themselves - Musical Guest | |
| Chris Elliott | ... | Himself - Plugging 'Skink, The Bounty Hunter' | |
| Gerard Mulligan | ... | Himself - Plugging 'Skink, The Bounty Hunter' | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amanda Peet | ... | Herself - Guest | |
| Patrick Warburton | ... | Himself - Guest | |
| Jeff Caldwell | ... | Himself - Guest / Stand Up Comedy Routine | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Susan Hum | ... | Herself (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jerry Seinfeld | ... | Himself - Guest | |
| Joe Torre | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Bill Scheft | ... | Himself - Writer |
| David Letterman | ... | Himself - Host | |
| Jennifer Connelly | ... | Herself - Guest | |
| Slash | ... | Himself - Guest | |
| Nicole Atkins | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer / Presenting 'This is your lunch' segment | |
| Johnny Dark | ... | Johnny Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| David Spade | ... | Himself - Guest | |
| Jonathan Papelbon | ... | Himself - Guest | |
| Penn Jillette | ... | Himself - Magical Performer (as Penn) | |
| Teller | ... | Himself - Magical Performer | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Johnny Dark | ... | Johnny - Cold Open Sketch (uncredited) | |
| Biff Henderson | ... | Himself - Eating a skunk (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Ryan Adams | ... | Himself - Musical Guest (as Ryan Adams and The Cardinals) | |
| The Cardinals | ... | Themselves - Musical Guest (as Ryan Adams and The Cardinals) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Joren Hodel | ... | Himself - 'Stupid Pet Tricks' Dog Owner | |
| Alan Kalter | ... | Himself - Announcer | |
| Willie Machado | ... | Himself - 'Stupid Pet Tricks' Dog Owner | |
| Bill Scheft | ... | Himself - Writer | |
| Irena Schulz | ... | Herself - 'Stupid Pet Tricks' Cockatoo Owner | |
| Lucia Vasquez | ... | Herself - 'Stupid Pet Tricks' Dog Owner | |
| Jude Brennan | ... | Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Murray | ... | Himself - Guest | |
| Jay-Z | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| George Vlosich | ... | Himself - Etch-A-Sketch Artist |
| David Letterman | ... | Himself - Host | |
| Robin Williams | ... | Himself - Guest | |
| Lupe Fiasco | ... | Himself - Musical Guest / Featuring Matt Santos | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Nancy Agostini | ... | Herself - Associate Producer | |
| Chris Albers | ... | Himself - Top Ten List Presenter | |
| Kenneth Bam Alexander | ... | Himself - Lupe Fiasco Band | |
| Steve Bodow | ... | Himself - Top Ten List Presenter | |
| Ron Buttler | ... | Himself - Questions to Dave | |
| Tim Carvell | ... | Himself - Top Ten List Presenter | |
| Larrance Dobson | ... | Himself - Lupe Fiasco Band | |
| Brian Donahue | |||
| Lamar Edwards | ... | Himself - Lupe Fiasco Band | |
| Nora Ephron | ... | Herself - Top Ten List Presenter | |
| Gina Gionfriddo | ... | Herself - Top Ten List Presenter | |
| Hal Gurnee | ... | Himself - Presenting 'Hal Gurnee's Network Timekiller' | |
| Charles Hamilton | ... | Himself - Lupe Fiasco Band | |
| Scott Iah | ... | Himself - Questions to Dave | |
| Angelo Iodice | ... | Himself - Performing 'Dance of the Boleadoras' | |
| Anna Jack | ... | Herself - Hula Hoop Girl | |
| Jim Jackoway | ... | Himself - Questions to Dave | |
| Kiva Kahl | ... | Herself - Grinder Girl | |
| Alan Kalter | ... | Himself - Announcer | |
| Jay Katsir | ... | Himself - Top Ten List Presenter | |
| Laura Krafft | ... | Herself - Top Ten List Presenter | |
| Warren Leight | ... | Himself - Top Ten List Presenter | |
| Una Mimnagh | ... | Herself - Performing 'Dance of the Boleadoras' | |
| Lisa Rime | ... | Herself - Questions to Dave | |
| Melissa Salmons | ... | Herself - Top Ten List Presenter | |
| Matthew Santos | ... | Himself - Musical Guest (as Matt Santos) | |
| Patricia Scalize | ... | Herself - Questions to Dave | |
| Bill Scheft | ... | Himself - Writer | |
| Alan Zweibel | ... | Himself - Top Ten List Presenter | |
| Hillary Rodham Clinton | ... | Herself - Pre-taped Cold Open Welcome (uncredited) | |
| Biff Henderson | ... | Himself - Stage Manager (uncredited) | |
| Walter Kim | ... | Scott Iha - Audience 'Writers Strike Questions and Answers' Participant (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Maher | ... | Himself - Guest | |
| Ellen Page | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Michael Bloomberg | ... | Himself - Awarding the Key to the City to Dave's beard | |
| Hal Gurnee | ... | Himself - Presenting 'Hal Gurnee's Network Timekiller' | |
| Roger Bart | ... | Dr. Frederick Frankenstein - From the Broadway musical 'Young Frankenstein' (uncredited) | |
| Christopher Fitzgerald | ... | Igor - From the Broadway musical 'Young Frankenstein' (uncredited) | |
| Sutton Foster | ... | Inga - From the Broadway musical 'Young Frankenstein' (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) |
| David Letterman | ... | Himself - Host | |
| Donald Trump | ... | Himself - Guest | |
| Shooter Jennings | ... | Himself - Musical Guest | |
| Sarah Billington | ... | Herself - Guest / Talent Co-ordinator | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive Producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tom Hanks | ... | Himself - Guest | |
| Mike Huckabee | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Roberto Patane | ... | Himself - Barber / Shaving Dave | |
| Diane Wood | ... | Herself - Barber / Shaving Dave | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Lucy Liu | ... | Herself - Guest | |
| Alexander Roy | ... | Himself - Guest (as Alex Roy) | |
| Mgmt | ... | Themselves - Musical Guest (as MGMT) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bill Medley | ... | Himself - Sitting in with the band | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Morgan Freeman | ... | Himself - Guest | |
| Tom Brokaw | ... | Himself - Guest | |
| Chuck Prophet | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Goose Gossage | ... | Himself - Presenting the Top Ten List | |
| Rupert Jee | ... | Himself - Presenting 'What's Rupert's Soup of the Day?' Segment | |
| John McCain | ... | Himself - Pre-taped segment / 'Late Show Candidate Spotlight' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Howard Stern | ... | Himself - Guest | |
| Ayo | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Chris Elliott | ... | Himself - Taking a break from 'WGA Picketing' | |
| John McCain | ... | Himself - Pre-taped segment / 'Late Show Candidate Spotlight' | |
| Gerard Mulligan | ... | Himself - Taking a break from 'WGA Picketing' | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Beth Ostrosky | ... | Herself - Sitting in the Green Room waving to the camera (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tracy Morgan | ... | Himself - Guest | |
| Katherine von Drachenberg | ... | Herself - Guest (as Kat Von D) | |
| Dropkick Murphys | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Anna Jack | ... | Herself - Hula-Hoop Girl | |
| Bill Scheft | ... | Himself - Late Show Strike Captain | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Katie Holmes | ... | Herself - Guest | |
| Frank Caliendo | ... | Himself - Guest | |
| Maroon 5 | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Adam Levine | ... | Himself | |
| James Valentine | ... | Himself | |
| Pat Farmer | ... | Himself - Stage Hand / Bringin in pizza for three guys in the audience (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer / Scratching a Lottery Ticket (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) | |
| Al Norwood | ... | Himself - Boom Operator (uncredited) |
| David Letterman | ... | Himself - Guest | |
| Denzel Washington | ... | Himself - Guest | |
| Don Rickles | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Harold Larkin | ... | Himself - Hailing a cab with a dead guy on an office chair (as Harold) | |
| Michael Z. McIntee | ... | Himself - Hailing a cab with a dead guy on an office chair (as Mike) | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Michael Douglas | ... | Himself - Guest | |
| Katherine Heigl | ... | Herself - Guest | |
| Wyclef Jean | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Gary Mintz | ... | Himself - Electronic Maintenance Engineer / Performing 'Gary-oke with Gary Mintz' | |
| Pat Farmer | ... | Himself - Stage Hand (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Sylvester Stallone | ... | Himself - Guest | |
| Paul Teutul Jr. | ... | Himself - Guest (as 'The Teutuls') | |
| Paul Teutul Sr. | ... | Himself - Guest (as 'The Teutuls') | |
| The Mars Volta | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Spinning the 'Late Show Prize Wheel' | |
| Alan Kalter | ... | Himself - Announcer | |
| Bruce Willis | ... | Himself - Sitting in with the band |
| Jim Gaffigan | ... | Himself | |
| Diane Keaton | ... | Herself |
| David Letterman | ... | Himself - Host | |
| Sarah Michelle Gellar | ... | Herself - Guest | |
| Dan Patrick | ... | Himself - Guest | |
| Ringo Starr | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Bruce Willis | ... | Himself - Pre-taped 'Bruce Willis Secret Word of the Night' segment | |
| Tracey B. Wilson | ... | Sketch Comedian | |
| David A. Stewart | ... | Himself - Musical Support / Guitar Player for Ringo Starr (uncredited) |
| David Letterman | ... | Himself - Host | |
| John Edwards | ... | Himself - Guest (as Senator John Edwards) | |
| Diablo Cody | ... | Herself - Guest | |
| Josh Ritter | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| David 'Fathead' Newman Jr. | ... | Himself - Sitting in with the band | |
| Tom Catusi | ... | Himself - Late Show Video Operator (uncredited) | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Rupert Jee | ... | Himself (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charles Grodin | ... | Himself - Guest | |
| Lawrence Tynes | ... | Himself - Guest | |
| The Redwalls | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Julia Louis-Dreyfus | ... | Herself - Guest | |
| T.J. Miller | ... | Himself - Guest | |
| Super Furry Animals | ... | Themselves - Musical Guest | |
| Barack Obama | ... | Himself - Top Ten List Presenter (as Senator Barack Obama) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Zohar Adner | ... | Himself - Stress Release Coach | |
| Donna Barnes | ... | Herself - Life and Relationship Coach | |
| Allan Fried | ... | Himself - Career Coach | |
| Judith Ann Graham | ... | Herself - Image Coach and Personal Stylist | |
| Andy Kindler | ... | Himself - Guest | |
| Mark Schwimmer | ... | Himself - Personal Development Facilitator | |
| Pat Farmer | ... | Himself - Stage Hand (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Nathan Lane | ... | Himself - Guest | |
| Jake Johannsen | ... | Himself - Guest / Stand-up Comedy Routine | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bill Scheft | ... | Himself - Writer | |
| Bruce Willis | ... | Himself - Pre-taped / Presenting 'Bruce Willis Secret Word of the Night' segment | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jessica Alba | ... | Herself - Guest | |
| Julie Chen | ... | Herself - Guest | |
| The Whigs | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Rupert Jee | ... | Himself - Supporting the WGA Strike | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Bill Scheft | ... | Himself - Late Show Strike Captain | |
| Johnny Dark | ... | Himself - Cold Open Sketch (uncredited) |
| David Letterman | ... | Himself - Host | |
| Bill Cosby | ... | Himself - Guest | |
| Lake Bell | ... | Herself - Guest | |
| The Matt Savage Trio | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Lena Headey | ... | Herself - Guest | |
| Gary Allan | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Eva Longoria Parker | ... | Herself - Guest | |
| Colbie Caillat | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Kyle Campbell | ... | Himself - Performing 'Stupid Human Tricks' | |
| Bradley Cheney | ... | Himself - Talking during 'Technical Maintenance Minute' (as Brad) | |
| Steve Hostomsky | ... | Himself - Talking during 'Technical Maintenance Minute' (as Steve) | |
| Scott Jacobson | ... | Himself - Performing 'Stupid Human Tricks' | |
| Gary Mintz | ... | Himself - Talking during 'Technical Maintenance Minute' (as Gary) | |
| Duncan Stephens | ... | Himself - Performing 'Stupid Human Tricks' | |
| Damon Warren | ... | Himself - Performing 'Stupid Human Tricks' | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Artie Lange | ... | Himself - Guest | |
| Vampire Weekend | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Tony Mendez | ... | Himself - Cue Card Boy / 'How it's made' Segment | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Hillary Rodham Clinton | ... | Herself - Guest (as Senator Hillary Clinton) | |
| Sheryl Crow | ... | Herself - Musical Guest | |
| Biff Henderson | ... | Himself - Reporting from the Super Bowl in Arizona | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tom Coughlin | ... | Himself - Being interviewed by Biff Henderson at the Super Bowl | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Matthew McConaughey | ... | Himself - Guest | |
| Gary Mule Deer | ... | Himself - Guest | |
| Sheryl Crow | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Eli Manning | ... | Himself - Guest | |
| Vince Vaughn | ... | Himself - Guest | |
| Alison Sudol | ... | Herself - Musical Guest (as A Fine Frenzy) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tony Mendez | ... | Goat Herder on 'Que Pasa USA!' | |
| Jude Brennan | ... | Dave's Wife (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Hudson | ... | Herself - Guest | |
| Jack Hanna | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Clark | ... | Himself - Reptile Expert / Handling a cobra | |
| Stephanie Birkitt | ... | Herself - Handing out prizes to the audience (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Colin Farrell | ... | Himself - Guest | |
| Blake Lively | ... | Herself - Guest | |
| Lenny Kravitz | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Susan Hum | ... | Herself - Hands one of Dave's old suits to a guy in the audience (as Sue) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Walsh | ... | Herself - Guest | |
| Jason Sudeikis | ... | Himself - Guest | |
| OK Go | ... | Themselves - Musical Guest | |
| Bonerama | ... | Themselves - Musical Guest (as OK Go and Bonerama) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager / Interviewing a person in the audience | |
| Alan Kalter | ... | Himself - Announcer (voice) (as Alan) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Phil McGraw | ... | Himself - Cameo / Getting punched out cold by a raging psycho in the audience (uncredited) |
| David Letterman | ... | Himself - Host | |
| Evangeline Lilly | ... | Herself - Guest | |
| Marisa Miller | ... | Herself - Guest | |
| Brad Paisley | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tom Catusi | ... | Himself - Late Show Video Operator | |
| George Clarke | ... | Himself - Getting a closer look at the 'Marissa Miller Sports Illustrated Billboard' (as George) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Michael Z. McIntee | ... | Cover Model for 'Mustache Aficionado Magazine' (uncredited) |
| David Letterman | ... | Himself - Host | |
| Martin Short | ... | Himself - Guest | |
| Amy Ryan | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (as Jude) | |
| Chris Elliott | ... | Himself / Bedlam - Plugging the new show 'American Conquistadors' | |
| Howard Hersh | ... | Himself - Musical Timpanist / Supporting Martin Short's Musical Act as Timpanist on the Kettle Drum | |
| Phil McGraw | ... | Himself - Laying unconscious on the floor (archive footage) (as Dr. Phil) | |
| Gerard Mulligan | ... | Himself - Plugging the new show 'American Conquistadors' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| Joseph Arthur | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Santiago Archila | ... | Himself - Audience Member participating in 'Audience Show & Tell' (also archive footage) | |
| Nelson Dudley | ... | Himself - Audience Member participating in 'Audience Show & Tell' | |
| Alan Kalter | ... | Himself - Announcer / Hosting 'Alan Kalter's Celebrity Interview' | |
| Andrea Lo | ... | Herself - Audience Member participating in 'Audience Show & Tell' | |
| Stephanie Birkitt | ... | Herself - Handing out prizes to the audience (uncredited) | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charles Barkley | ... | Himself - Guest | |
| Bill Burr | ... | Himself - Guest / Stand-Up Comedy Routine | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Dennis Quaid | ... | Himself - Guest | |
| Ryan Newman | ... | Himself - Guest | |
| Sharon Jones | ... | Herself - Musical Guest (as 'Sharon Jones and The Dap Kings') | |
| Dap-Kings | ... | Themselves - Musical Guests (as 'Sharon Jones and The Dap Kings') | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Johnny Dark | ... | Johnny Lincoln (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Randy Jackson | ... | Himself - Guest | |
| Saffron Burrows | ... | Herself - Guest | |
| Ray Davies | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Interviewing members in the audience | |
| Sid McGinnis | ... | Himself - Late Show Band Guitarist / Displaying his new beard-style (as Sid) | |
| Bill Scheft | ... | Himself - Late Show Writer | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amy Sedaris | ... | Herself - Guest | |
| Erika Jensen | ... | Herself - Guest | |
| Foo Fighters | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager / Starting the grocery bagging contest (as Biff) | |
| Kid Rock | ... | Himself - Appearing in 'Paul Shaffer's Rock of Love' Segment | |
| Emeril Lagasse | ... | Himself - Top Ten List Presenter | |
| Martha Stewart | ... | Herself - Top Ten List Presenter | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Gary Mintz | ... | Raul Castro - Calling Dave on the phone (uncredited) (voice) | |
| Karen Weatherwax | ... | Marci - Girl in 'Paul Shaffer's Rock of Love' Segment (uncredited) |
| David Letterman | ... | Himself - Host | |
| Steve Martin | ... | Himself - Guest | |
| Chris Elliott | ... | Himself - Guest Plugging 'Chris and Gerry's Kitchen Nightmares' | |
| Raymond Crowe | ... | Himself - Performing Guest / Hand Shadow Magician | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Mary Goggin | ... | Hostess | |
| Gerard Mulligan | ... | Himself - Surprise Guest Plugging 'Chris and Gerry's Kitchen Nightmares' | |
| Eric Ripert | ... | Himself - Executive Chef at Le Bernardin in 'Chris and Gerry's Kitchen Nightmares' | |
| Stephanie Birkitt | ... | Herself - Handing out prizes to members of the audience (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Gary Mintz | ... | Raul Castro (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Sean 'P. Diddy' Combs | ... | Himself - Guest (as Sean 'Diddy' Combs) | |
| Al Lubel | ... | Himself - Guest / Stand-up comedy routine | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Victoria Lilly | ... | Herself - Paul Shaffer's Daughter / Waving to the camera from the green room | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Ferrell | ... | Himself - Guest | |
| Michael McDonald | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Borden | ... | Himself - Writer / Resembling a guy in a 'Small Town News' clip | |
| Brian Donahue | |||
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Peyton List | ... | Von Trapp Kid (uncredited) | |
| Gary Mintz | ... | Raul Castro - Voice on the phone with Dave (uncredited) (voice) | |
| Scarlett Sperduto | ... | Von Trapp Kid (uncredited) | |
| Jaclyn Tommer | ... | Von Trapp Kid singing with Will Ferrell (uncredited) |
| David Letterman | ... | Himself - Host | |
| Courteney Cox | ... | Herself - Guest | |
| Thomas Friedman | ... | Himself - Guest | |
| Chingy | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Ray Benson | ... | Himself - Musical Support / Sitting in with the band | |
| Ludacris | ... | Himself - Musical support for Chingy | |
| Bobby Valentino | ... | Himself - Musical support for Chingy (as Bobby) | |
| Jeff Altman | ... | Lt. Len Easton of the California Highway Patrol (uncredited) (voice) | |
| Gary Mintz | ... | Raul Castro - Voice on the phone with Dave (uncredited) (voice) | |
| Richard Scheckman | ... | Contest winner wearing a red dress (uncredited) |
| David Letterman | ... | Himself - Host | |
| Natalie Portman | ... | Herself - Guest | |
| Kenna | ... | Himself - Musical Guest | |
| Pharrell Williams | ... | Himself - Musical Support for Kenna's Performance | |
| Chad Hugo | ... | Himself - Musical Support for Kenna's Performance | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Louis J. Aronne | ... | Himself - Medical Doctor / 'Andy Kindler at Toy Fair -08' Segment | |
| Lisa R. Callahan | ... | Herself - Medical Doctor / 'Andy Kindler at Toy Fair -08' Segment (as Lisa Callahan) | |
| Kristen French | ... | Herself - Kid Scientist | |
| Andy Kindler | ... | Himself - Guest / Presenting 'Andy Kindler at Toy Fair -08' Segment | |
| Sam Mather | ... | Himself - Kid Scientist | |
| James Murray | ... | Himself - Audio Engineer / 'Andy Kindler at Toy Fair -08' Segment (as Jim Murray) | |
| Victor Wang | ... | Himself - Kid Scientist |
| David Letterman | ... | Himself - Host | |
| Amy Adams | ... | Herself - Guest | |
| Jamie Oliver | ... | Himself - Guest | |
| Liam Finn | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Hillary Rodham Clinton | ... | Herself - Appearing in pre-taped segment 'A Message From Hillary Clinton' especially recorded for The Late Show (as Hillary Clinton) | |
| Scot Haney | ... | Himself - Meteorologist / Telling Dave about the upcoming weather report | |
| Jude Brennan | ... | Herself - Executive Producer / Telling Dave about the guests (uncredited) | |
| Tony Mendez | ... | Himself - Cue Card Boy / Getting sprayed with water by Dave (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Woody Harrelson | ... | Himself - Guest | |
| Tommy Tiernan | ... | Himself - Guest / Stand-up Comedy Routine | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jim Carrey | ... | Himself - Guest | |
| Paula Abdul | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Walking out on Dave's bulls**t (as Dave) | |
| Pat Farmer | ... | Himself - Stage Hand / Spinning the 'Late Show Prize Wheel' (as Pat) | |
| Alan Kalter | ... | Himself - Announcer (as Alan) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Gary Mintz | ... | Gov. Eliot Spitzer - Talking to Dave on the phone (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Martha Stewart | ... | Herself - Guest | |
| Snoop Dogg | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Charlize Theron | ... | Herself - Guest | |
| Lewis Black | ... | Himself - Guest | |
| British Sea Power | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Al Chez | ... | Himself - CBS Orchestra Musician / Being commended by Dave | |
| Alan Kalter | ... | Himself - Announcer | |
| Natalie Pero | ... | Mobster's Girlfriend | |
| Gerard Mulligan | ... | Eliot Spitzer - Answering questions from the viewers (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Beckinsale | ... | Herself - Guest | |
| Graham Colton | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Doug Benefield | ... | Himself - Professional Turkey Gobbler | |
| George Clarke | ... | Himself - Building Engineer / Presenting 'It's A Fact with George Clarke' | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Stephan Richardson | ... | Himself - Professional Turkey Gobbler | |
| Scott Wilhelm | ... | Himself - Professional Turkey Gobbler | |
| Johnny Dark | ... | Johnny Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jaime Pressly | ... | Herself - Guest | |
| Brian Regan | ... | Himself - Guest / Stand-up Comedy Act | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Karen Weatherwax | ... | Mom in 'Dave's Store' | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rainn Wilson | ... | Himself - Guest | |
| Mike Golic | ... | Himself - Guest | |
| Mike Greenberg | ... | Himself - Guest | |
| Bell X1 | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Al Franken | ... | Himself - Guest | |
| Lauren Conrad | ... | Herself - Guest | |
| The Cribs | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Hosting 'What's In The Soup?' Contest | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Brooke Shields | ... | Herself - Guest | |
| Seth Meyers | ... | Himself - Guest | |
| The Gutter Twins | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Dave - Drunk Camera Operator | |
| Alan Kalter | ... | Himself - Announcer | |
| Jamie Bamber | ... | Lee Adama / Top Ten List Presenter (uncredited) | |
| James Callis | ... | Gaius Baltar / Top Ten List Presenter (uncredited) | |
| Aaron Douglas | ... | Galen Tyrol / Top Ten List Presenter (uncredited) | |
| Tricia Helfer | ... | Number Six / Top Ten List Presenter (uncredited) | |
| Michael Hogan | ... | Saul Tigh / Top Ten List Presenter (uncredited) | |
| Lucy Lawless | ... | D'Anna Biers / Top Ten List Presenter (uncredited) | |
| Mary McDonnell | ... | Laura Roslin / Top Ten List Presenter (uncredited) | |
| Edward James Olmos | ... | William Adama / Top Ten List Presenter (uncredited) | |
| Grace Park | ... | Lt. Sharon Valerii / Top Ten List Presenter (uncredited) | |
| Katee Sackhoff | ... | Kara Thrace / Top Ten List Presenter (uncredited) |
| David Letterman | ... | Himself - Host | |
| Demi Moore | ... | Herself - Guest | |
| Anthony Bourdain | ... | Himself - Guest | |
| Counting Crows | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Jude Brennan | ... | Herself - Executive Producer / Cold Open Sketch (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kate Bosworth | ... | Herself - Guest | |
| John Witherspoon | ... | Himself - Guest | |
| The Raveonettes | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Brian Williams | ... | Himself - Guest | |
| Judy Greer | ... | Herself - Guest | |
| Langhorne Slim | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Helen Mirren | ... | Herself - Guest | |
| Jose Canseco | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Joba Chamberlain | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Billy Crystal | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Shelley Duncan | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Joe Girardi | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Biff Henderson | ... | Himself - Visiting The Yankees spring training | |
| Derek Jeter | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Alan Kalter | ... | Himself - Announcer | |
| Mickey Rivers | ... | Himself - Attending New York Yankee's spring traning in Tampa | |
| Alex Rodríguez | ... | Himself - Attending New York Yankee's spring traning in Tampa (as Alex Rodriguez) | |
| José Veras | ... | Himself - Attending New York Yankee's spring traning in Tampa (as Jose Veras) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| John McCain | ... | Himself - Guest (as Senator John McCain) | |
| Cat Power | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| George Clooney | ... | Himself - Guest | |
| Norah Jones | ... | Herself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Renée Zellweger | ... | Herself - Guest (as Renee Zellweger) | |
| Gayle King | ... | Herself - Guest | |
| Paddy Casey | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Stage Hand / Dropping baseballs from the The Ed Sullivan Theatre roof dressed as a New York Yankee | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ellen Pompeo | ... | Herself - Guest | |
| Jay-Z | ... | Himself - Guest / Also Musical Guest | |
| Mary J. Blige | ... | Herself - Guest / Also Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Al Pacino | ... | Himself - Guest | |
| David Wright | ... | Himself - Guest | |
| Trevor Immelman | ... | Himself - Presenting the Top Ten List | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Slipping with the camera while doing his taxes at the final moment (as Dave) | |
| Alan Kalter | ... | Himself - Announcer (voice) |
| David Letterman | ... | Himself - Host | |
| Kelsey Grammer | ... | Himself - Guest | |
| Kristen Bell | ... | Herself - Guest | |
| Rogue Wave | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| William Bregman | ... | Himself - Accountant / Top Ten List Presenter | |
| Saundra Bussel | ... | Herself - Accountant / Top Ten List Presenter | |
| Richard Cohen | ... | Himself - Accountant / Top Ten List Presenter | |
| Lou DeFalco | ... | Himself - Accountant / Top Ten List Presenter | |
| Arthur Drucker | ... | Himself - Accountant / Top Ten List Presenter | |
| Steven Goldstein | ... | Himself - Accountant / Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer | |
| Richard Koenigsberg | ... | Himself - Accountant / Top Ten List Presenter | |
| Vicki Penino | ... | Herself - Accountant / Top Ten List Presenter | |
| Andrew Ross | ... | Himself - Accountant / Top Ten List Presenter | |
| Andrew Rubin | ... | Himself - Accountant / Top Ten List Presenter | |
| Chris Elliott | ... | President John Adams (uncredited) | |
| Gerard Mulligan | ... | Master Artist - Painting a presidential portrait (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Uma Thurman | ... | Herself - Guest | |
| Graham Rahal | ... | Himself - Guest | |
| The Gossip | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Gary Mintz | ... | Gary Mintz - Technical Engineer Superhero that saves the day | |
| Chris Elliott | ... | President John Adams (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Gerard Mulligan | ... | Friend of President John Adams (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kelly Ripa | ... | Herself - Guest | |
| Dr. John P. Holdren | ... | Himself - Guest | |
| The Black Keys | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Jude Brennan | ... | Executive Producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Amy Poehler | ... | Herself - Guest | |
| Jason Segel | ... | Himself - Guest | |
| Jordan Zevon | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Tom Malone | ... | Himself - CBS Orchestra Musician / Examining his Baritone Saxophone (as Tom) | |
| Chris Elliott | ... | President John Adams (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Billy Crystal | ... | Himself - Guest | |
| Maria Sharapova | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Sean Avery | ... | Himself - New York Ranger / Getting in i fistfight with Chris in 'Chris Elliott's Wacky World of Hockey' segment | |
| Chris Elliott | ... | Himself - Playing with The New York Rangers (segment "Chris Elliott's Wacky World of Hockey") | |
| Scott Gomez | ... | Himself - New York Ranger / Wondering if Chris can skate (segment "Chris Elliott's Wacky World of Hockey") | |
| Henrik Lundqvist | ... | Himself - New York Ranger / Making fun of Chris (segment "Chris Elliott's Wacky World of Hockey") | |
| Gerard Mulligan | ... | Himself - Following Chris (segment "Chris Elliott's Wacky World of Hockey") | |
| Brendan Shanahan | ... | Himself - New York Ranger / Helping Chris with his protective cup (segment "Chris Elliott's Wacky World of Hockey") | |
| Fredrik Sjöström | ... | Himself - New York Ranger / Making fun of Chris in Swedish in 'Chris Elliott's Wacky World of Hockey' segment | |
| Susan Hum | ... | Herself - Costume Designer / Helping Chris with his hockey pants (segment "Chris Elliott's Wacky World of Hockey") (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Helen Hunt | ... | Herself - Guest | |
| Chris 'Mad Dog' Russo | ... | Himself - Guest | |
| Kathleen Edwards | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Messing with his cameras colour settings | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Danica Patrick | ... | Herself - Guest | |
| Keith Olbermann | ... | Himself - Guest | |
| Tokyo Police Club | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Johnny Dark | ... | President Abraham Lincoln (uncredited) | |
| Chris Elliott | ... | President John Adams / Mac Computer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Gerard Mulligan | ... | PC Computer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tina Fey | ... | Herself - Guest | |
| Brett Favre | ... | Himself - Guest | |
| Estelle | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Craig Ferguson | ... | Himself - Guest | |
| Ira Glass | ... | Himself - Guest | |
| The Black Crowes | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Modelling for a balloon portrait | |
| Todd Neufeld | ... | Himself - Balloon Artist | |
| Chris Elliott | ... | President John Adams (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Gerard Mulligan | ... | Abigail Smith Adams (uncredited) |
| David Letterman | ... | Himself - Host | |
| Gwyneth Paltrow | ... | Herself - Guest | |
| Richard Lewis | ... | Himself - Guest | |
| The Roots | ... | Themselves - Musical Guest | |
| Chrisette Michele | ... | Herself - Musical Guest / Musical Support for The Roots | |
| Wale Folarin | ... | Himself - Musical Guest / Musical Support for The Roots (as Wale) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Going away to wait in line for the GTA IV release (as Dave) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Robert Downey Jr. | ... | Himself - Guest | |
| Alicia Keys | ... | Herself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself - Trying to hail a taxi dressed as Spider-Man (as George) | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Matthew Broderick | ... | Himself - Guest | |
| Heidi Montag | ... | Herself - Guest | |
| Josh Groban | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Marty Reisman | ... | Himself - Surprise Cameo / Shoots down a cigarette with a ping pong ball | |
| Biff Henderson | ... | Himself - Stage Manager (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| John Goodman | ... | Himself - Guest | |
| Bear Grylls | ... | Himself - Guest | |
| Robyn Carlsson | ... | Herself - Musical Guest (as Robyn) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barack Obama | ... | Himself - Top Ten List Presenter (as Senator Barack Obama) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Joshua King | ... | Boy (uncredited) | |
| Isabella Palmieri | ... | Little girl (uncredited) | |
| Jaclyn Tommer | ... | Dancing Girl #2 in May-Day Skit with John Goodman (uncredited) |
| David Letterman | ... | Himself - Host | |
| Patrick Dempsey | ... | Himself - Guest | |
| Isabella Rossellini | ... | Herself - Guest | |
| Nick Lowe | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Johnson | ... | Himself - Interviewed by Dave over the phone (voice) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Jimmy Kimmel | ... | Himself - Guest | |
| Jimmy Eat World | ... | Themselves - Musical Guest | |
| Lance Burton | ... | Himself - Master Magician | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Jonathan Aldridge | ... | Himself | |
| Hillary Rodham Clinton | ... | Herself - Top Ten List Presenter / Pre-taped segment (as Senator Hillary Clinton) | |
| Pat Farmer | ... | Himself - Stage Hand / Spinning the 'Late Show Prize Wheel' | |
| Biff Henderson | ... | Himself - Stage Manager | |
| Alan Kalter | ... | Himself - Announcer | |
| Regis Philbin | ... | Himself - Being killed by the 'Late Show Prize Wheel' (uncredited) |
| David Letterman | ... | Himself - Host | |
| Ashton Kutcher | ... | Himself - Guest | |
| Mac King | ... | Himself - Guest Magician | |
| Stevie Winwood | ... | Himself - Musical Guest (as Steve Winwood) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Johnny Dark | ... | Johnny Twain (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Emile Hirsch | ... | Himself - Guest | |
| Tom Dreesen | ... | Himself - Guest | |
| Dirk Arthur | ... | Himself - Extreme Magician | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Chris De Troy | ... | Himself - Getting a tattoo / Segment 'Andy Kindler Visits a tattoo parlor' | |
| Andy Kindler | ... | Himself - Special Guest | |
| Michelle Myles | ... | Herself - Tattoo Parlor Artist and Dare Devil Tattoo Owner (Segment 'Andy Kindler Visits a tattoo parlor') | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Paris Hilton | ... | Herself - Guest | |
| Panic! At The Disco | ... | Themselves - Musical Guest (as Panic At The Disco) | |
| Steve Wyrick | ... | Himself - Magician | |
| Dorothy Mengering | ... | Herself - Top Ten List Presenter | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself | |
| Benji Madden | ... | Himself - Waiting in the green room | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Barbara Walters | ... | Herself - Guest | |
| Cobie Smulders | ... | Herself - Guest | |
| Penn Jillette | ... | Himself - Guest Magician (as Penn) | |
| Teller | ... | Himself - Guest Magician | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Shia LaBeouf | ... | Himself - Guest | |
| N.E.R.D. | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself | |
| Biff Henderson | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Darryl Kraemer | ... | Himself | |
| Jennifer Rota | ... | Herself | |
| Katie Tucker | ... | Herself - Owner of 'Stupid Pet Tricks' participant dog Pyro |
| David Letterman | ... | Himself - Host | |
| Regis Philbin | ... | Himself - Guest | |
| Laura Dern | ... | Herself - Guest | |
| Death Cab for Cutie | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Jack Hanna | ... | Himself - Guest | |
| Kid Rock | ... | Himself - Guest / Musical Guest | |
| Annika Sorenstam | ... | Herself - Top Ten List Presenter | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | B.J. Twain (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| America Ferrera | ... | Herself - Guest | |
| Russell Brand | ... | Himself - Guest | |
| Terry Fator | ... | Himself - Guest / Ventriloquist Performer | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Ryan Simonetti | ... | Himself | |
| Olivia Stackhouse | ... | Herself - Ryan's Girlfriend / Driving the U-Haul | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Teri Hatcher | ... | Herself - Guest | |
| Robert Kennedy Jr. | ... | Himself - Guest (as Robert F. Kennedy Jr.) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Stage Hand / Saving a 'lady' from falling of the balcony | |
| Biff Henderson | ... | Himself - Stage Manager / Saving a 'lady' from falling of the balcony | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kevin Spacey | ... | Himself - Guest | |
| James Webb | ... | Himself - Guest (as Senator Jim Webb) | |
| Sara Bareilles | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (voice) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Harrison Ford | ... | Himself - Guest | |
| Ali Lohan | ... | Herself - Guest | |
| Leona Lewis | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Kristin Davis | ... | Herself - Guest | |
| Jimmy Buffett | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself | |
| Bill Scheft | ... | Himself - Late Show Strike Captain | |
| Paul Teutul Jr. | ... | Himself - Receives a visit from Biff Henderson at OCC | |
| Michael Teutul | ... | Himself - Receives a visit from Biff Henderson at OCC | |
| Paul Teutul Sr. | ... | Himself - Receives a visit from Biff Henderson at OCC | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Sarah Jessica Parker | ... | Herself - Guest | |
| Republic Tigers | ... | Themselves - Musical Guest (as The Republic Tigers) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Derek DeRoche | ... | Himself - Piedmont Birdcalling Champion | |
| Jackie Gage | ... | Herself - Piedmont Birdcalling Contestant | |
| Anna Kritikos | ... | Herself - Piedmont Birdcalling Contestant | |
| Katharine Marley | ... | Herself - Piedmont Birdcalling Contestant | |
| James Meagher | ... | Himself - Piedmont Birdcalling Contestant | |
| Lillian Meagher | ... | Herself - Piedmont Birdcalling Contestant | |
| Eric Sezgen | ... | Himself - Piedmont Birdcalling Champion | |
| Eric Wheeler | ... | Himself - Piedmont Birdcalling Champion | |
| Harrison Ford | ... | Himself (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Tony Mendez | ... | Himself - Cue Card Boy (uncredited) |
| David Letterman | ... | Himself - Host | |
| Liv Tyler | ... | Herself - Guest | |
| Sue Johanson | ... | Herself - Guest | |
| Tommy Johnagin | ... | Himself - Guest / Stand-up Comedy Performer | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Adam Sandler | ... | Himself - Guest | |
| Scott Dixon | ... | Himself - Guest | |
| Donna Summer | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Explains what he found in his chili | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Julianne Moore | ... | Herself - Guest | |
| Morgan Spurlock | ... | Himself - Guest | |
| Becca Ayers | ... | Ensign Cora MacRae | |
| Margot de La Barre | ... | Ensign Connie Walewska | |
| Laura Marie Duncan | ... | Ensign Dinah Murphy | |
| Laura Griffith | ... | Ensign Janet MacGregor | |
| Lisa Howard | ... | Lt. Genevieve Marshall | |
| Garret Long | ... | Ensign Sue Yaeger | |
| Kelli O'Hara | ... | Ensign Nellie Forbush | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Billy Crystal | ... | Himself - Surprise Guest / Shows up unscheduled with a pony | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Jack Black | ... | Himself - Guest | |
| Scott McClellan | ... | Himself - Guest (credit only) | |
| Esperanza Spalding | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Barbara Gaines | ... | Herself - Executive producer | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | B.J. Twain (uncredited) |
| David Letterman | ... | Himself - Host | |
| Julia Roberts | ... | Herself - Guest | |
| Al Green | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Billy Crystal | ... | Himself - Surprise Guest / Shows up unscheduled with a pony | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Jenna Fischer | ... | Herself - Guest | |
| Jim Nantz | ... | Himself - Guest | |
| Gavin Rossdale | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Tom Brokaw | ... | Himself - Guest | |
| Elettra Wiedemann | ... | Herself - Guest | |
| Gnarls Barkley | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pamela Ahn | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Emma Coleman | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Sean Hallarman | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Biff Henderson | ... | Himself - Stage Manager / Interviewing people in the audience (as Biff) | |
| David Hinojosa | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Claudia Kiss | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Mark Odgers | ... | Himself - Jumping over 7 interns on 53rd Street | |
| Eliot Rahal | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Zach Smilovitz | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Mark Wahlberg | ... | Himself - Guest | |
| Jeff Peckman | ... | Himself - Guest | |
| Alanis Morissette | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager / Checking in on Dave due to the heat affecting the elderly | |
| Susan Hum | ... | Herself - Bringing Dave some fresh tomato | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Zooey Deschanel | ... | Herself - Guest | |
| Scott McClellan | ... | Himself - Guest | |
| Jakob Dylan | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Regis Philbin | ... | Himself - Surprise Cameo / Host's a special edition of 'Million Dollar Password' | |
| Jude Brennan | ... | Rosanna Perkins - Contestant on 'Million Dollar Password' (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Ben Kingsley | ... | Himself - Guest (as Sir Ben Kingsley) | |
| Artie Lange | ... | Himself - Guest | |
| Emmylou Harris | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Billy Crystal | ... | Himself - Brings a public service announcement with Dave / Pre-taped sketch | |
| Barbara Gaines | ... | Herself - Executive producer | |
| Alan Kalter | ... | Himself - Announcer | |
| Tony Mendez | ... | Himself - Cue Card Boy / Revealing 'What's In The Cargo Shorts?' | |
| Gary Mintz | ... | Himself - Talks during 'Technical Maintenance Minute' |
| David Letterman | ... | Himself - Host | |
| Whoopi Goldberg | ... | Herself - Guest | |
| Spencer Pratt | ... | Himself - Guest | |
| Nick Griffin | ... | Himself - Guest / Stand-up Comedy Performer | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pamela Ahn | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Emma Coleman | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Sean Hallarman | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| David Hinojosa | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Claudia Kiss | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Heidi Montag | ... | Herself - Cameo / Talking with Dave while waiting in the green room | |
| Mark Odgers | ... | Himself - Jumping over 8 interns on 53rd Street | |
| Eliot Rahal | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Zach Smilovitz | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Jessica Snyder | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Mike Myers | ... | Himself - Guest | |
| Kevin Robinson | ... | Himself - Guest | |
| Adele | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bob Borden | ... | Himself - Writer / Resembling a guy in a 'Small Town News' clip | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Steve Carell | ... | Himself - Guest | |
| Lance Armstrong | ... | Himself - Guest | |
| Dr. John | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Host"s "Would You Like To Take A Vacation Photo With Dave?" Segment | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kevin Garnett | ... | Himself - Guest | |
| Ray Allen | ... | Himself - Guest | |
| Jane Krakowski | ... | Herself - Guest | |
| Martha Wainwright | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Congratulating Dave on being able to get a gay marriage | |
| Joe Grossman | ... | Joe Grossman - Rejected by 22 Colleges | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Jason Bateman | ... | Himself - Guest | |
| Teri Garr | ... | Herself - Guest | |
| Keyshia Cole | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tony Mendez | ... | Himself - Cue Card Boy / Talks to the 'Chevron CEO' | |
| Bill Scheft | ... | Himself - Late Show Strike Captain | |
| Johnny Dark | ... | Francis Albert Lincoln (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Spencer Pratt | ... | Himself - Guest (archive footage) (uncredited) |
| David Letterman | ... | Himself - Host | |
| Denis Leary | ... | Himself - Guest | |
| The Baseball Project | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pamela Ahn | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Emma Coleman | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Sean Hallarman | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Rebecca Hilton | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| David Hinojosa | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Alan Kalter | ... | Himself - Announcer | |
| Ashley LoBue | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Mark Odgers | ... | Himself - Jumping over 10 interns on 53rd Street | |
| Eliot Rahal | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Zach Smilovitz | ... | Himself - Late Show Intern / Being jumped over on 53rd Street | |
| Jessica Snyder | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Holly Valdes | ... | Herself - Late Show Intern / Being jumped over on 53rd Street | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Will Smith | ... | Himself - Guest | |
| Joe Buck | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| George Clarke | ... | Himself - Mistaken for a pregnant man | |
| Alan Kalter | ... | Himself - Announcer |
| David Letterman | ... | Himself - Host | |
| Charlize Theron | ... | Herself - Guest | |
| Richard Belzer | ... | Himself - Guest | |
| Mötley Crüe | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Hosts 'Psychic Gasoline' | |
| Deborah Lynn | ... | Herself - Playing 'Psychic Gasoline' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Abigail Breslin | ... | Herself - Guest | |
| Barry Sonnenfeld | ... | Himself - Guest | |
| Tift Merritt | ... | Herself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Overlooks the 'Slip 'n Slide' | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Mary-Kate Olsen | ... | Herself - Guest | |
| Jim Gaffigan | ... | Himself - Guest | |
| Gavin DeGraw | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Mark Odgers | ... | Himself - Jumps 10 interns and dunks a basketball on 53rd Street | |
| Tom Catusi | ... | Himself - Late Show Video Operator (uncredited) | |
| Joe Grossman | ... | Rudy - Lyle's Friend (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Morgan Freeman | ... | Himself - Guest | |
| Kaley Cuoco | ... | Herself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Pierce Brosnan | ... | Himself - Guest | |
| Bud Selig | ... | Himself - Guest | |
| Jason Mraz | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Meryl Streep | ... | Herself - Guest | |
| Aaron Eckhart | ... | Himself - Guest | |
| Randy Travis | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Derek Jeter | ... | Himself - Top Ten List Presenter | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Maggie Gyllenhaal | ... | Herself - Guest | |
| Neil Young | ... | Himself - Guest | |
| The Hold Steady | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Bobby Drake | ... | Himself - Documented by Andy Kindler | |
| Craig Finn | ... | Himself | |
| Andy Kindler | ... | Himself - Special Guest / Documenting a 'The Hold Steady' concert | |
| Tad Kubler | ... | Himself - Documented by Andy Kindler | |
| Franz Nicolay | ... | Himself - Documented by Andy Kindler | |
| Galen Polivka | ... | Himself - Documented by Andy Kindler | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Ricky Gervais | ... | Himself - Guest | |
| John Mellencamp | ... | Himself - Guest / Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Dave Dorsett | ... | Himself - Camera Operator / Show's up late for work | |
| Johnny Dark | ... | B.J. Twain (uncredited) | |
| Joe Grossman | ... | Rudy - Lyle's Friend (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) | |
| Jimmi Simpson | ... | Lyle the Intern (uncredited) |
| David Letterman | ... | Himself - Host | |
| Rosie Perez | ... | Herself - Guest | |
| David Sedaris | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Brad Emehiser | ... | Himself - Skateboards on Broadway | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Will Ferrell | ... | Himself - Guest | |
| Adam Savage | ... | Himself - Guest | |
| Jamie Hyneman | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Amanda Peet | ... | Herself - Guest | |
| Jon Hamm | ... | Himself - Guest | |
| Augustana | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Helps Amanda Peet to calm down | |
| Bill Scheft | ... | Himself - Returns from hip replacement surgery | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| John C. Reilly | ... | Himself - Guest | |
| Jane Mayer | ... | Herself - Guest | |
| Grizzly Bear | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| David Duchovny | ... | Himself - Guest | |
| Black Kids | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Shannon Eis | ... | Herself - Presents 'New Summer Toys' | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Nathan Lane | ... | Himself - Guest | |
| Larry Brown | ... | Himself - Guest (as Larry 'Bubbles' Brown) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Randy Bachman | ... | Himself | |
| Pat Farmer | ... | Himself - Stage Hand | |
| Alan Kalter | ... | Himself - Announcer | |
| Paul Thoresen | ... | Himself | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Gillian Anderson | ... | Herself - Guest | |
| Simon Pegg | ... | Himself - Guest | |
| We Are Scientists | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Tony Mendez | ... | Himself - Cue Card Boy | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Kevin Costner | ... | Himself - Guest | |
| Bob Sarlatte | ... | Himself - Guest | |
| Low vs Diamond | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rupert Jee | ... | Himself - Host's 'Hot enough for you?' | |
| Alan Kalter | ... | Himself - Announcer | |
| Johnny Dark | ... | Bob Lubin (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Pamela Anderson | ... | Herself - Guest | |
| James Franco | ... | Himself - Guest | |
| Atmosphere | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Stage Manager / Brings out christmas ornaments (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Luke Wilson | ... | Himself - Guest | |
| Mindy Kaling | ... | Herself - Guest | |
| Michel Lauziere | ... | Himself - Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself - Gives Dave a brush-off | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Richard Simmons | ... | Himself - Guest | |
| Mary-Louise Parker | ... | Herself - Guest | |
| Dwayne Kennedy | ... | Himself - Guest / Stand-up Comedian (credit only) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Paul Thoresen | ... | Himself - Drops a waterballoon on a car |
| David Letterman | ... | Himself - Host | |
| Seth Rogen | ... | Himself - Guest | |
| Fleet Foxes | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Rob DeDora | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer | |
| Sarah-Simone McDougall | ... | Herself | |
| Alisa Wayland | ... | Herself | |
| Chris Elliott | ... | Himself (uncredited) | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) | |
| Gerard Mulligan | ... | Himself (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself - Host | |
| Kelly Ripa | ... | Herself - Guest | |
| Steve Coogan | ... | Himself - Guest | |
| Spiritualized | ... | Themselves - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Michael Z. McIntee | ... | Ticket Scalper (uncredited) |
| David Letterman | ... | Himself - Host | |
| Penélope Cruz | ... | Herself - Guest | |
| Danny Way | ... | Himself - Guest | |
| Randy Newman | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Demetrius Andrade | ... | Himself | |
| Howard Bach | ... | Himself | |
| Kyle Bennett | ... | Himself | |
| Georgina Bloomberg | ... | Herself | |
| Casey Burgener | ... | Himself | |
| Chris Elliott | ... | Himself | |
| Allyson Felix | ... | Herself | |
| Biff Henderson | ... | Himself | |
| Eva Lee | ... | Herself | |
| Ivan Lee | ... | Himself | |
| Steven Lopez | ... | Himself | |
| Bob Malaythong | ... | Himself | |
| Kate Markgraf | ... | Herself | |
| Misty May-Treanor | ... | Herself | |
| Gerard Mulligan | ... | Himself (as Gerry Mulligan) | |
| Heather O'Reilly | ... | Herself | |
| Donny Robinson | ... | Himself | |
| Abby Wambach | ... | Herself | |
| Rau'Shee Warren | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Kiefer Sutherland | ... | Himself - Guest | |
| Rumer Willis | ... | Herself - Guest | |
| Phil Vassar | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Chris Elliott | ... | Himself - Gives Green Tips | |
| Gerard Mulligan | ... | Himself - Gives Green Tips | |
| Jude Brennan | ... | (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Donald Trump | ... | Himself - Guest | |
| Dwayne Kennedy | ... | Himself - Guest / Stand-up Comedian | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Alan Kalter | ... | Himself - Announcer | |
| Anna Jack | ... | Herself - Hula Hoop Girl (uncredited) | |
| Kiva Kahl | ... | Herself - Grinder Girl (uncredited) | |
| Rute | ... | Herself - Late Show Model (uncredited) | |
| Andrea Sande | ... | Herself - Late Show Model (uncredited) |
| David Letterman | ... | Himself | |
| Shawn Johnson | ... | Herself | |
| Tracy Morgan | ... | Himself | |
| Solange Knowles | ... | Herself | |
| Paul Shaffer | ... | Himself | |
| Dave Dorsett | ... | Himself | |
| Barbara Gaines | ... | Herself (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Bryan Clay | ... | Himself - Guest | |
| Don Cheadle | ... | Himself - Guest | |
| Little Anthony and the Imperials | ... | Themselves - Musical Guest (as Little Anthony & The Imperials) | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Howard Dean | ... | Himself | |
| Biff Henderson | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Kerri Walsh | ... | Herself - Guest | |
| Misty May-Treanor | ... | Herself - Guest | |
| Neil Patrick Harris | ... | Himself - Guest | |
| Nas | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself | |
| Tony Mendez | ... | Himself | |
| Barbara Gaines | ... | Herself (uncredited) | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Brad Garrett | ... | Himself - Guest | |
| Blake Lively | ... | Herself - Guest | |
| Randy Houser | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Biff Henderson | ... | Himself | |
| Gayle King | ... | Herself - Meets Biff Henderson | |
| G. Terry Madonna | ... | Himself (as Dr. G. Terry Madonna) | |
| Bob Schieffer | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Amy Sedaris | ... | Herself - Guest | |
| Kimberly Kardashian | ... | Herself - Guest (as Kim Kardashian) | |
| Brian Regan | ... | Himself - Guest / Stand-up Comedian | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Pat Farmer | ... | Himself - Stage Hand | |
| Biff Henderson | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (voice) | |
| Paul Thoresen | ... | Himself | |
| Barbara Gaines | ... | Herself - Executive producer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Nicolas Cage | ... | Himself - Guest | |
| Anna Torv | ... | Herself - Guest | |
| Terrence Howard | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Andy Kindler | ... | Himself | |
| Alan Kalter | ... | Himself - Announcer (uncredited) (voice) |
| David Letterman | ... | Himself - Host | |
| Phil McGraw | ... | Himself - Guest (as Dr. Phil) | |
| Tilda Swinton | ... | Herself - Guest | |
| Tricky | ... | Himself - Musical Guest | |
| Paul Shaffer | ... | Himself - Band Director / Musical Supervisor | |
| Joe Grossman | ... | Joe Grossman - Sex Addict | |
| Andy Kindler | ... | Himself | |