 | Michael Gross | ... | Steven Keaton (176 episodes, 1982-1989) |

| Michael J. Fox | ... | Alex P. Keaton (176 episodes, 1982-1989) |

| Justine Bateman | ... | Mallory Keaton (176 episodes, 1982-1989) |
 | Tina Yothers | ... | Jennifer Keaton (176 episodes, 1982-1989) |

| Meredith Baxter | ... | Elyse Keaton (171 episodes, 1982-1989) |
 | Brian Bonsall | ... | Andrew 'Andy' Keaton (78 episodes, 1986-1989) |
 | Marc Price | ... | Irwin 'Skippy' Handelman (54 episodes, 1982-1989) |
 | Scott Valentine | ... | Nick Moore (44 episodes, 1985-1989) |

| Courteney Cox | ... | Lauren Miller (21 episodes, 1987-1989) |
 | Tracy Pollan | ... | Ellen Reed (12 episodes, 1985-1987) |
 | John Hancock | ... | Gus Thompson (7 episodes, 1983-1989) |
 | Robert Schanche | ... | Sam / ... (6 episodes, 1983-1989) |
 | Enid Kent | ... | Phyllis / ... (6 episodes, 1982-1988) |
 | Terry Wills | ... | Dr. Schulte / ... (6 episodes, 1983-1989) |
 | Norman Parker | ... | Robert Keaton (6 episodes, 1985-1987) |

| Alan Blumenfeld | ... | George Bellack / ... (6 episodes, 1984-1987) |
 | John Petlock | ... | Ted Waterman / ... (5 episodes, 1982-1986) |
 | Robert Costanzo | ... | Carmine / ... (5 episodes, 1984-1987) |
 | David Wohl | ... | Psychiatrist / ... (5 episodes, 1985-1988) |
 | John Dukakis | ... | Jeff Wakefield (4 episodes, 1983-1984) |
 | Ben Piazza | ... | Mr. Wertz / ... (4 episodes, 1984-1987) |
 | Michael David Wright | ... | Young Steven / ... (4 episodes, 1984-1988) |

| Tom Hanks | ... | Ned Donnelly (3 episodes, 1983-1984) |

| John Putch | ... | Neil / ... (3 episodes, 1982-1986) |
 | Timothy Busfield | ... | Doug / ... (3 episodes, 1984-1986) |
 | Bunny Summers | ... | Customer #1 / ... (3 episodes, 1983-1985) |
 | Belita Moreno | ... | Bernice / ... (3 episodes, 1983-1988) |
 | Walter Olkewicz | ... | Bill Channing / ... (3 episodes, 1984-1987) |
 | Matthew Faison | ... | Dr. Skip Williamson / ... (3 episodes, 1985-1987) |

| Michael B. Moynahan | ... | Grover Garver / ... (3 episodes, 1983-1986) |
 | Denise D'Amico | ... | Customer #2 / ... (3 episodes, 1985-1989) |
 | James N. Hamilton | ... | Bellhop / ... (3 episodes, 1985-1987) |
 | Margaret Marx | ... | Young Elyse (3 episodes, 1986-1988) |
 | Raymond Singer | ... | Buffaloed Bill / ... (3 episodes, 1986-1988) |
 | Melinda Culea | ... | Rebecca Ryan (3 episodes, 1986-1987) |
 | Jane Adams | ... | Marty Brodie / ... (3 episodes, 1987-1989) |

| Richard McGonagle | ... | Brother Timothy / ... (3 episodes, 1987-1989) |

| Philip Baker Hall | ... | Dr. Harrison (3 episodes, 1988) |
 | Anne Seymour | ... | May Keaton (2 episodes, 1985) |
 | Priscilla Morrill | ... | Kate / ... (2 episodes, 1982-1984) |

| Sal Viscuso | ... | Richard Grasso / ... (2 episodes, 1982-1984) |
 | Mary Farrell | ... | Carol Mannings / ... (2 episodes, 1983-1985) |
 | Richard Venture | ... | Mr. Carlyle (2 episodes, 1983) |
 | Adam Carl | ... | Young Steven Keaton (2 episodes, 1985) |
 | Philip Sterling | ... | Mr. Winkler (2 episodes, 1982-1984) |
 | Brooke Alderson | ... | Suzanne Davis (2 episodes, 1982-1983) |
 | Jay Tarses | ... | Ron Davis (2 episodes, 1982-1983) |

| Sam Whipple | ... | Bill / ... (2 episodes, 1984) |

| Daphne Zuniga | ... | Rachel Miller (2 episodes, 1984) |
 | Rick Podell | ... | Jackie Jackerman (2 episodes, 1985) |

| Jeffrey Joseph | ... | James Jarrett (2 episodes, 1984-1985) |
 | Earl Boen | ... | Attendant / ... (2 episodes, 1983-1984) |

| Geena Davis | ... | Karen Nicholson (2 episodes, 1984) |

| Jack Blessing | ... | Leonard (2 episodes, 1985) |

| David Paymer | ... | Larry Harris (2 episodes, 1985) |
 | Chris Hebert | ... | Young Alex (2 episodes, 1982-1983) |
 | Michael Alldredge | ... | Young Jake Keaton (2 episodes, 1985) |
 | Karlene Crockett | ... | Marge (2 episodes, 1985) |
 | Julie Fulton | ... | Suzie / ... (2 episodes, 1985) |
 | Maryedith Burrell | ... | Young May (2 episodes, 1985) |
 | Mark Marias | ... | Young Robert Keaton (2 episodes, 1985) |
 | Ron Karabatsos | ... | Bud Carlson (2 episodes, 1985) |
 | Hanna Hertelendy | ... | Mrs. Kretzer (2 episodes, 1985) |
 | Wiley Harker | ... | Mr. Kretzer (2 episodes, 1985) |

| Robert Martin Steinberg | ... | Neighbor (2 episodes, 1985) |
 | Barbara Barron | ... | Neighbor (2 episodes, 1985) |

| Edward Edwards | ... | Mr. Rubin Tedesco / ... (2 episodes, 1983-1986) |
 | Lois De Banzie | ... | Mrs. Rose Handleman / ... (2 episodes, 1984-1989) |
 | Michael Zorek | ... | Flaum (2 episodes, 1984-1986) |
 | Tracy Nelson | ... | Deena / ... (2 episodes, 1984-1985) |

| Dan Hedaya | ... | Joe Moore (2 episodes, 1988-1989) |

| Joseph Gordon-Levitt | ... | Dougie (2 episodes, 1988) |
 | Raleigh Bond | ... | Harry Handleman / ... (2 episodes, 1984-1989) |
 | John Hostetter | ... | Anchorman / ... (2 episodes, 1984-1987) |
 | Bernadette Birkett | ... | Carol / ... (2 episodes, 1985-1988) |
 | Jeff Cohen | ... | Dougie Barker / ... (2 episodes, 1984-1987) |

| Ford Austin | ... | Todd (2 episodes, 1984-1985) |

| Marc Wasserman | ... | Ted (2 episodes, 1984-1985) |
 | Garrett Merriman | ... | Baby Andrew 'Andy' Keaton (2 episodes, 1985-1986) |
 | Taylor Merriman | ... | Baby Andrew 'Andy' Keaton (2 episodes, 1985-1986) |
 | Suzanne Snyder | ... | Tricia Armstrong (2 episodes, 1985) |

| Anne Bellamy | ... | Boardwoman / ... (2 episodes, 1987-1989) |
 | Jason Naylor | ... | Simon Wickerson (2 episodes, 1987-1989) |
 | Julie Cobb | ... | Maureen Keaton (2 episodes, 1987) |

| Alyson Croft | ... | Brooke (2 episodes, 1987) |

| Sonia Curtis | ... | Amy Sussman (2 episodes, 1987) |
 | Gino De Mauro | ... | Zack (2 episodes, 1987) |
 | Stephanie Dizon | ... | Holly (2 episodes, 1987) |
 | Niall Gartlan | ... | Brett (2 episodes, 1987) |
 | Heather Hobbs | ... | Stacie Connors (2 episodes, 1987) |
 | Tammy Lauren | ... | Marilyn Keaton (2 episodes, 1987) |

| Amy Lynne | ... | Chrissy Nardino (2 episodes, 1987) |

| Brian McNamara | ... | Greg (2 episodes, 1987) |
 | Wendel Meldrum | ... | Kathy Brady (2 episodes, 1987) |
 | Nicole Nourmand | ... | Beth (2 episodes, 1987) |
 | Fess Reynolds | ... | Reggie (2 episodes, 1987) |
 | Blake Soper | ... | Jonathan Keaton (2 episodes, 1987) |
 | Meg Wyllie | ... | Mrs. Leahy (2 episodes, 1987) |

| Kevin Dunn | ... | Bob / ... (2 episodes, 1988-1989) |
 | Baillie Gerstein | ... | Mrs. Hummier / ... (2 episodes, 1988-1989) |
 | Billy Morrissette | ... | Paul Corman / ... (2 episodes, 1988-1989) |
 | Bibi Besch | ... | Dr. Hewitt (2 episodes, 1988) |

| Christian Clemenson | ... | Mr. Flaherty (2 episodes, 1988) |
 | Richard Kuss | ... | Mr. Meyers (2 episodes, 1988) |
 | Caroline Mignini | ... | Peggy Vincent (2 episodes, 1988) |
 | Christina Pickles | ... | Ruth Hobart (2 episodes, 1988) |
 | Keith Amos | ... | Michael Thompson (2 episodes, 1989) |
 | Rosalind Cash | ... | Maya Thompson (2 episodes, 1989) |

| Mark L. Taylor | ... | Phil (2 episodes, 1989) |
|
| Dianne Edwards Thorington | .... | production assistant / assistant: Gary Goldberg (73 episodes, 1982-1987) |
| Merilynn Marko-Sanders | .... | script supervisor (73 episodes, 1982-1987) |
| Parker Roe | .... | technical director (71 episodes, 1982-1987) |
| Andrew McCullough | .... | stage manager (70 episodes, 1982-1987) |
| Robert Schanche | .... | production assistant (61 episodes, 1982-1987) |
| Linda Nieber | .... | production assistant (60 episodes, 1982-1987) |
| Bruce Bryant | .... | title designer / main title designer (56 episodes, 1983-1987) |
| James Castle | .... | title designer / main title designer (56 episodes, 1983-1987) |
| Denise Alexander | .... | production assistant (52 episodes, 1983-1987) |
| Richard Allen | .... | stage manager (51 episodes, 1983-1987) |
| Elaine Arata | .... | production assistant (48 episodes, 1982-1987) |
| Sharl Scharfer-Rollins | .... | production assistant (48 episodes, 1983-1987) |
| Ana Krewson | .... | production assistant (45 episodes, 1983-1987) |
| Ruth Bennett | .... | executive story consultant / story editor (44 episodes, 1982-1987) |
| Rosie Dean | .... | production coordinator (44 episodes, 1987-1989) |
| Shari Genser | .... | production assistant (41 episodes, 1983-1987) |
| Michael Shelley | .... | production assistant (28 episodes, 1983-1985) |
| Jim Hamilton | .... | production assistant (28 episodes, 1984-1987) |
| Gary Palmer | .... | technical consultant (26 episodes, 1984-1987) |
| Alan Uger | .... | executive script consultant (24 episodes, 1983-1987) |
| Heidi Schulte | .... | production assistant (23 episodes, 1982-1983) |
| Valery Garrett | .... | production assistant (21 episodes, 1982-1983) |
| Michael J. Weithorn | .... | story consultant (21 episodes, 1982-1983) |
| Celeste Hines | .... | production assistant (18 episodes, 1983-1987) |
| Janice Pober | .... | production assistant (15 episodes, 1982-1983) |
| Elizabeth Ward | .... | stage manager / production assistant / ... (15 episodes, 1982-1983) |
| Jessie Ward Dugan | .... | production assistant / program coordinator (13 episodes, 1985-1987) |
| Terry Fleming | .... | production assistant (12 episodes, 1985-1987) |
| Marc Lawrence | .... | story editor (11 episodes, 1985-1987) |
| Debby Maffioli | .... | production assistant (11 episodes, 1985-1987) |
| Lisa Onodera | .... | production assistant (11 episodes, 1985-1987) |
| Carol Johnsen | .... | title designer (11 episodes, 1985) |
| Bill Moya | .... | production assistant (7 episodes, 1982-1983) |
| Paul Ross Newman | .... | production assistant (7 episodes, 1982-1983) |
| Joanne Pagliaro | .... | story editor (4 episodes, 1982-1983) |
| Michael Villegas III | .... | production assistant (4 episodes, 1983) |
| Carlo Quinterio | .... | stage manager (4 episodes, 1984) |
| Judy Biggs | .... | production assistant (4 episodes, 1985-1987) |
| Susan Borowitz | .... | story editor (4 episodes, 1985-1987) |
| Jim MacNerland | .... | production assistant (4 episodes, 1985-1987) |
| Craig Zisk | .... | production assistant (4 episodes, 1985-1987) |
| Harriette Regan | .... | stage manager (2 episodes, 1983-1984) |
| Adam Scott | .... | stage manager (2 episodes, 1985-1987) |
|
| Charles Croughwell | .... | stand-in: Mr. Fox (unknown episodes, 1984-1989) |
| Pablo Ferro | .... | title designer: main titles (unknown episodes) |
| |