The character of J.J. Hunsecker is based on famed New York columnist Walter Winchell.
Hunsecker's apartment building is actually the show-business office tower at 1619 Broadway, also known as the Brill Bldg., a famous part of Tin Pan Alley.
One of the musical refrains that is repeated throughout the film was used nearly note for note in Boogie Nights (1997).
This film's shoot was filled with macho tensions and at one point, the temperamental Burt Lancaster threatened to punch the film's writer, Ernest Lehman. The witty scribe replied, "Go ahead, I need the money."
The movie's line "I'd hate to take a bite outta you. You're a cookie full of arsenic" was voted as the #99 of "The 100 Greatest Movie Lines" by Premiere in 2007.
Orson Welles was initially suggested for the role of J.J. Hunsecker.
In 2000, on their self-titled album, rock band Kitty Kat Stew released a song called "Cookie Full Of Arsenic". The song's lyrics relate to the movie and incorporates a snippet of its actual dialogue, featuring the famous line.
The narc in the film, Lt Harry Kello, is based on NYPD detective Eddie Egan, immortalized by Gene Hackman as 'Popeye' Doyle in The French Connection (1971).
Robert Vaughn originally landed the part of Steve Dallas, but was drafted into the Army before he could film any footage.
In the opening shots of Manhattan, the movie The Mountain (1956) starring Robert Wagner and Spencer Tracy, is shown playing at a movie house. The Mountain came out one year before Sweet Smell of Success.